p53 Activator III, RITA;≥97% (HPLC)

别名:5,5'-(2,5-呋喃二基)二-2-噻吩甲醇;NSC 652287;2,5双(5-羟甲基-2-噻吩基)呋喃;2,5- bis-(5-Hydroxymethyl-2-thienyl)-furan;Reactivation of p53 and Induction of Tumor cell Apoptosis, MDM2 Antagonist VII, MDM2 Inhibitor X, p53 Activator III, RITA

CAS号 213261-59-7 经验分子式(希尔表示法) C14H12O3S2 分子量 292.37
货号(SKU): 506149
CAS号: 213261-59-7
MDL号: MFCD03235294
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¥1,356.00

说明

一般描述

A cell-permeable, p53-targeting, tricyclic thiophene derivative that displays antitumor properties. Blocks p53—MDM2 interaction and p53 ubiquitination and induces p53-dependent apoptosis in tumor cells expressing wild-type p53. Shown to restore the tumor suppressor function of p53 by inducing its accumulation in HCT116 colon carcinoma cells (~0.1 µM) and in p53-positive SCID mice xenografted with HCT116 cells (0.1, 1 or 10 mg/kg, ip) in vivo.
A cell-permeable, p53-targeting, tricyclic thiophene derivative that displays antitumor properties. Blocks p53—MDM2 interaction and p53 ubiquitination and induces p53-dependent apoptosis in tumor cells expressing wild-type p53. Shown to restore the tumor suppressor function of p53 by inducing its accumulation in HCT116 colon carcinoma cells (~0.1 µM) and in p53-positive SCID mice xenografted with HCT116 cells (0.1, 1 or 10 mg/kg, ip) in vivo.
 

生化/生理作用

Cell permeable: yes
Primary Target
p53
Product does not compete with ATP.
Reversible: no
 

警告

Toxicity: Irritant (B)
 

重悬

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
 

其他说明

Grinkevich, V., et al. 2005. Nat. Med.11, 1136.
Krajewski, M., et al. 2005. Nat. Med.11, 1135.
Issaeva, N., et al. 2004. Nat. Med.10, 1321.
Nieves-Neira, W., et al. 1999. Mol. Pharmacol.56, 478.
Rivera, M.I., et al. 1999. Biochem. Pharmacol.57, 1283.
 

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
 
 

属性

质量水平

检测方案

≥97% (HPLC)

形式

crystalline solid

manufacturer/tradename

Calbiochem®

储存条件

OK to freeze
protect from light

溶解性

ethanol: 1 mg/mL
DMSO: 3 mg/mL

运输

ambient

储存温度

2-8°C

InChI

1S/C14H12O3S2/c15-7-9-1-5-13(18-9)11-3-4-12(17-11)14-6-2-10(8-16)19-14/h1-6,15-16H,7-8H2

InChI key

KZENBFUSKMWCJF-UHFFFAOYSA-N

 

安全信息

储存分类代码

11 - Combustible Solids

WGK

WGK 1

商品规格
属性名称属性值
储存温度 Storage temp.-20°C低温冷冻
全球实时库存 Availability √美国St. Louis ≥ 20 | 欧洲Eur. ≥ 16 | 東京Tokyo ≥ 5 | 香港与北京 ≥ 20
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