L-甲状腺素，L-Thyroxine [T4]；Pharmaceutical Secondary Standard; Certified Reference Material

图片 L-甲状腺素，L-Thyroxine [T4]；Pharmaceutical Secondary Standard; Certified Reference Material
别名：L-甲状腺素标准品；3,3′,5,5″-四碘代-L-甲状腺原氨酸；3-[4-(4-羟基-3,5-二碘苯氧基)-3,5-二碘苯基]-L-丙氨酸；3,3′,5,5″-Tetraiodo-L-thyronine, 3-[4-(4-Hydroxy-3,5-diiodophenoxy)-3,5-diiodophenyl]-L-alanine, T4

线性分子式: HOC6H2(I)2OC6H2(I)2CH2CH(NH2)CO2H CAS号: 51-48-9 分子量: 776.87 Beilstein: 2228515 EC 号: 200-101-1 MDL编号: MFCD00002595 PubChem化学物质编号: 329823509 NACRES: NA.24
制造商品牌: 色谱科 Supelco , 西格玛 Sigma-Aldrich
货号（SKU）: PHR1613
CAS号: 51-48-9
MDL号: MFCD00002595
签订合同 √ 正规发票 √ 技术支持 √ 质量保障 √ 全程可追溯 √
¥1,050.00

说明

一般描述

Levothyroxine is a thyroid hormone that is responsible for the physiological actions such as growth, cardiac functionality, and regulation of carbohydrates, lipid, and protein metabolisms.[1]
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.
 

应用

Levothyroxine may be used as a pharmaceutical reference standard for the quantification of the analyte in pharmaceutical formulations and bulk dosage forms[2][3] and oral liquid formulations[1] by chromatography.
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.
 

生化/生理作用

L甲状腺素 (T4) 和三碘代-L-甲状腺原氨酸 (T3) 为含碘激素，由甲状腺卵泡细胞中的甲状腺球蛋白制备。这些激素对代谢率的刺激以及对生长发展的调节似乎归因于它们对 DNA 转录的作用，进而影响蛋白质的合成。
 

分析说明

These secondary standards offer multi-traceability to the USP, EP and BP primary standards, where they are available.
 

其他说明

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.
 

附注

To see an example of a Certificate of Analysis for this material enter LRAC1514 in the slot below. This is an example certificate only and may not be the lot that you receive.
 
 

属性

等级

certified reference material
pharmaceutical secondary standard

质量水平

300

Agency

traceable to Ph. Eur. L0570000
traceable to USP 1365000

CofA

current certificate can be downloaded

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

mp

223 °C (dec.) (lit.)

application(s)

pharmaceutical (small molecule)

格式

neat

储存温度

2-30°C

SMILES string

N[C@@H](Cc1cc(I)c(Oc2cc(I)c(O)c(I)c2)c(I)c1)C(O)=O

InChI

1S/C15H11I4NO4/c16-8-4-7(5-9(17)13(8)21)24-14-10(18)1-6(2-11(14)19)3-12(20)15(22)23/h1-2,4-5,12,21H,3,20H2,(H,22,23)/t12-/m0/s1

InChI key

XUIIKFGFIJCVMT-LBPRGKRZSA-N

Gene Information

human ... THRA(7067) , THRB(7068)

 

安全信息

储存分类代码

11 - Combustible Solids

WGK

WGK 3

商品规格
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储存温度 Storage temp.-20°C低温冷冻
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