本品是非甾体类抗炎药,动物模型中观察到其有抗炎、镇痛和退热的作用。本品的作用机理是通过抑制环氧化酶-2(COX-2)来抑制前列腺素生成。且在人体治疗浓度下，本品对同工酶—环氧化酶-1(COX-1)没有抑制作用。在动物结肠肿瘤模型中塞来昔布减缓了肿瘤的发生和进展。
Application
Celecoxib has been used as an inhibitor of cyclooxygenase-2 (COX-2) in pre-treatment and in the chemotherapy regimen in bladder cancer cells. It has also been used in studying its inhibitory effect on the cell viability and proliferation in human prostate cancer cell line (PC-3).
Biochem/physiol Actions
Celecoxib is majorly bound to plasma proteins and is eliminated from liver via cytochrome P450 metabolic pathway. Celecoxib is recommended drug for the management of inflammation in osteoarthritis and rheumatoid arthritis. It may be effective in treating colorectal cancer in combination with chemoradiotherapy.
塞来昔布是非甾体抗炎药（NSAID）和环氧合酶-2（COX-2）选择性抑制剂。与 COX-1 相比，塞来昔布对 COX-2 的选择性至少高 10-20 倍。性质
| grade | ≥99.0%, HPLC |
| SMILES string | Cc1ccc(cc1)-c2cc(nn2-c3ccc(cc3)S(N)(=O)=O)C(F)(F)F| InChI | 1S/C17H14F3N3O2S/c1-11-2-4-12(5-3-11)15-10-16(17(18,19)20)22-23(15)13-6-8-14(9-7-13)26(21,24)25/h2-10H,1H3,(H2,21,24,25)| InChI key | RZEKVGVHFLEQIL-UHFFFAOYSA-N| Gene Information： | human ... PTGS2(5743) | | | |
安全信息
