生物活性小分子, Small Molecules

包含多种强效选择性探针,可调节所有通路和主要靶标类别的靶标活性;可为您的神经科学、基因调控、ADME/Tox、免疫学、离子通道和脂质信号传导、细胞凋亡和细胞周期、细胞因子和生长因子药物发现工作流程提供支持。

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盐酸布帕西布,Buparlisib Hydrochloride;≥99% (HPLC)

B06208
别名:布帕西布盐酸盐;5-[2,6-Di(4-morpholinyl)-4-pyrimidinyl]-4-(trifluoromethyl)-2-pyridinamine

CAS:1312445-63-8;分子式:C18H22ClF3N6O2;分子量:446.85
¥1,550.00

布帕西布,Buparlisib [BKM120];≥99% (HPLC)

B06209
别名:5-[2,6-二(4-吗啉基)-4-嘧啶基]-4-(三氟甲基)-2-吡啶胺;5-[2,6-Di(4-morpholinyl)-4-pyrimidinyl]-4-(trifluoromethyl)-2-pyridinamine;BKM-120

CAS:944396-07-0;分子式:C18H21F3N6O2;分子量:410.39
¥632.00

Duvelisib,[IPI-145, INK1197];≥99% (HPLC)

D06210
别名:8-Chloro-2-phenyl-3-[(1S)-1-(9H-purin-6-ylamino)ethyl]-1(2H)-isoquinolinone;(S)-3-(1-((9H-嘌呤-6-基)氨基)乙基)-8-氯-2-苯基-1(2H)-异喹啉酮

CasNo:1201438-56-3;MDL:MFCD15144635;分子式:C22H17ClN6O;分子量:416.86
¥755.00

GDC-0941,[PI 3-K Inhibitor XXI];≥99% (HPLC)

5.09226
别名;GDC0941;Pictrelisib;2-(1H-吲唑-4-基)-6-(4-甲磺酰哌嗪-1-基甲基)-4-吗啉-4-基-噻吩并[3,2-d]嘧啶;2-(1H-Indazol-4-yl)-6-(4-methylsulfonyl-piperazin-1-ylmethyl)-4-morpholin-4-yl-thieno[3,2- d]pyrimidine;4-(2-(1H-Indazol-4-yl)-6-((4-(methylsulfonyl)piperazin-1-yl)methyl)thieno[3,2-d]pyrimidin-4-yl)morpholine;2-(1H-吲唑-4-基)-6-(4-甲烷磺酰基哌嗪-1-基甲基)-4-吗啉-4-基-噻吩并[3,2-d]嘧

Empirical Formula (Hill Notation): C23H27N7O3S2 CAS号: 957054-30-7 分子量: 513.64
¥926.00

卡博替尼苹果酸盐,Cabozantinib malate;≥99% (HPLC)

C06212
别名:苹果酸卡博替尼;XL184;Cabozantinib S-malate;N-(4-((6,7-dimethoxyquinolin-4-yl)oxy)phenyl)-N-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide (S)-2-hydroxysuccinate;N-(4-((6,7-二甲氧基喹啉-4-基)氧基)苯基)-N-(4-氟苯基)环丙烷-1,1-二甲酰胺(S)-2-羟基丁二酸盐

CAS:1140909-48-3;分子式:C32H30FN3O10;分子量:635.60
¥943.00

KRN633,≥98% (HPLC)

SML0957
别名:KRN-633;N-[2-Chloro-4-[(6,7-dimethoxy-4-quinazolinyl)oxy]phenyl]-N′-propyl-urea;N-[2-氯-4-[(6,7-二甲氧基-4-喹唑啉基)氧基]苯基]-N'-丙基脲

Empirical Formula (Hill Notation): C20H21ClN4O4 CAS号: 286370-15-8 分子量: 416.86 NACRES: NA.77
¥1,456.76

Ki8751,[VEGFR2 Kinase Inhibitor VI];≥97% (HPLC)

676484
别名:N-(2,4-Difluorophenyl)-Nʹ-(4-(6,7-dimethoxy-4-quinolyloxy)-2-fluorophenyl)urea, Vascular Endothelial Growth Factor Receptor 2 Kinase Inhibitor VI, VEGFR Tyrosine Kinase Inhibitor XXIV, VEGFR2 Kinase Inhibitor VI, 1-(2,4-二氟苯基)-3-(4-((6,7-二甲氧基喹啉-4-基)氧基)-2-氟苯基)脲

Empirical Formula (Hill Notation): C24H18F3N3O4 CAS号: 228559-41-9 分子量: 469.41
¥3,830.84

NVP-BAW2881,≥99% (HPLC)

B06215
别名:BAW2881;6-((2-氨基-4-嘧啶基)氧基)-N-(3-(三氟甲基)苯基)-1-萘甲酰胺;6-((2-aminopyrimidin-4-yl)oxy)-N-(3-(trifluoromethyl)phenyl)-1-naphthamide

CAS:861875-60-7;分子式:C22H15F3N4O2;分子量:424.38
¥1,462.00

A 83-01,[TGF-β RI Kinase Inhibitor IV];≥98% (HPLC)

SML0788
别名:TGF-β RI 激酶抑制剂 IV;ALK4、5和7激酶抑制剂;A-83-01;A83-01;3-(6-甲基-2-吡啶基)-N-苯基-4-(4-喹啉基)-1H-吡唑-1-硫代甲酰胺;3-(6-Methyl-2-pyridinyl)-N-phenyl-4-(4-quinolinyl)-1H-pyrazole-1-carbothioamide

Empirical Formula (Hill Notation): C25H19N5S CAS号: 909910-43-6 分子量: 421.52 NACRES: NA.77
¥1,028.85

罗拉替尼,Lorlatinib;≥98% (HPLC)

PZ0039
别名:PF-06463922;PF-6463922;(10R)-7-氨基-12-氟-2,10,16-三甲基-15-氧代-10,15,16,17-四氢-2H.8,4-(甲基)吡唑并[4,3.h ] [2,5,11]-苯并二氮杂二环十四癸-3-甲腈;(10R)-7-Amino-12-fluoro-2,10,16-trimethyl-15-oxo-10,15,16,17-tetrahydro-2H.8,4-(metheno)pyrazolo[4,3.h][2,5,11]-benzoxadiazacyclotetradecine-3-carbonitrile

Empirical Formula (Hill Notation): C21H19FN6O2 CAS号: 1924207-18-0 分子量: 406.41 MDL编号: MFCD28144520
¥1,281.78

罗拉替尼醋酸盐,Lorlatinib acetate [PF-06463922 acetate];≥98% (HPLC)

PZ0271
别名:醋酸洛拉替尼;罗拉替尼乙酸盐;PF-06463922;PF-6463922;(10R).7-氨基-12-氟-2,10,16-三甲基-15-氧代-10,15,16,17-四氢-2H.8,4-(甲基)吡唑并[4,3.h ] [2,5,11]-苯并二氮杂二环十四癸-3-乙酸乙腈;(10R).7-Amino-12-fluoro-2,10,16-trimethyl-15-oxo-10,15,16,17-tetrahydro-2H.8,4-(metheno)pyrazolo[4,3.h][2,5,11]-benzoxadiazacyclotetradecine-3-carbonitrile acetate, Lorlatinib acetate

Empirical Formula (Hill Notation): C21H19FN6O2 · CH3COOH CAS号: 1924207-18-0 分子量: 466.46 PubChem化学物质编号: 329823805 NACRES: NA.77
¥1,437.71

GNF-2,≥98% (HPLC), solid

G9420
别名:3-[6-[[4-(三氟甲氧基)苯基]氨基]-4-嘧啶基]苯甲酰胺;Bcr-abl Inhibitor;3-[6-[[4-(Trifluoromethoxy)phenyl]amino]-4-pyrimidinyl]benzamide

Empirical Formula (Hill Notation): C18H13F3N4O2 CAS号: 778270-11-4 分子量: 374.32 MDL编号: MFCD09265253 PubChem化学物质编号: 24724498 NACRES: NA.77
¥2,226.10