醛固酮，Aldosterone；≥95% (HPLC)

图片 醛固酮，Aldosterone；≥95% (HPLC)
别名：18-Aldocorticosterone, Reichstein X, 11β,21-Dihydroxy-3,20-dioxo-4-pregnen-18-al, 11β,21-Dihydroxypregn-4-ene-3,18,20-trione Empirical Formula (Hill Notation): C21H28O5 CAS号: 52-39-1 分子量: 360.44 Beilstein: 3224996 EC 号: 200-139-9 MDL编号: MFCD00051136 PubChem化学物质编号: 24891458 NACRES: NA.77
制造商品牌: 西格玛 Sigma-Aldrich
货号（SKU）: A9477
CAS号: 52-39-1
MDL号: MFCD00051136
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说明

醛固酮是一种具有生物活性的醛固酮异构体； 由肾上腺皮质产生的盐皮质激素。 它诱导 K+ 的尿排泄和 Na+ 的肾重吸收。 它由促肾上腺皮质激素 (ACTH) 产生，对于维持远端小管中的钠稳态至关重要。 醛固酮与盐皮质激素受体结合，可调节血管系统并诱发肾脏损伤。 它有助于慢性肾病（CKD）的进展。 醛固酮是肾素-血管紧张素-醛固酮系统 (RAAS) 的一部分。

应用

Aldosterone has been used:
  • as a RPMI-1640 medium supplement for podocyte culture to test its pathogenicity in obesity-related glomerulopathy (ORG)
  • in combination with salt to induce renal injury in mice
  • to stimulate primary liver sinusoidal endothelial cells (LSECs) and in the generation of hyperaldosteronism model in mice
The d-isomer of aldosterone is considered to be the biologically active isomer.
 

生化/生理作用

Aldosterone is a biologically active aldosterone isomer; a mineralocorticoid produced by the adrenal cortex. It induces urinary excretion of K+ and renal reabsorption of Na+. It is produced from adrenocorticotropic hormone (ACTH) and is essential for maintaining sodium homeostasis in the distal tubules. Aldosterone binds to the mineralocorticoid receptor and may modulate vascular system and induce kidney damage. It contributes to the progression of chronic kidney disease(CKD). Aldosterone is part of the renin-angiotensin-aldosterone system (RAAS).

其他说明

Exists as an equilibrium mixture of the aldehyde and the hemiacetal.
 
 

属性

质量水平

200

生物来源

synthetic (organic)

无菌性

non-sterile

测定

≥95% (HPLC)

形式

powder

应用

cell culture | mammalian: suitable

溶解性

chloroform: 20 mg/mL, clear to slightly hazy, colorless to light yellow

运输

ambient

储存温度

room temp

SMILES string

C[C@]12CCC(=O)C=C1CC[C@H]3[C@@H]4CC[C@H](C(=O)CO)[C@]4(C[C@H](O)[C@H]23)C=O

InChI

1S/C21H28O5/c1-20-7-6-13(24)8-12(20)2-3-14-15-4-5-16(18(26)10-22)21(15,11-23)9-17(25)19(14)20/h8,11,14-17,19,22,25H,2-7,9-10H2,1H3/t14-,15-,16+,17-,19+,20-,21+/m0/s1

InChI key

PQSUYGKTWSAVDQ-ZVIOFETBSA-N

Gene Information

human ... SERPINA6(866)
rat ... Ar(24208) , Nr3c2(25672)

 

安全信息

Storage Class Code

13 - Non Combustible Solids

WGK Germany

WGK 3

个人防护装备

Eyeshields, Gloves, type N95 (US)

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