| Catalogue Number | H105250 |
| Chemical Name | Harmine |
| Synonyms | 7-Methoxy-1-methyl-9H-pyrido[3,4-b]indole; 1-Methyl-7-methoxy-β-carboline; Banisterin; Banisterine; Harmin; Leucoharmine; Telepathin; Telepathine; Yagein; Yageine; |
| CAS Number | 442-51-3 |
| Molecular Formula | C13H12N2O |
| Appearance | White to Brown Solid |
| Melting Point | >164ºC (dec.) |
| Molecular Weight | 212.25 |
| Storage | Refrigerator |
| Solubility | DMSO (Slightly), Methanol (Slightly, Heated) |
| Category | Standards; Neurochemicals; Pharmaceutical/API Drug Impurities/Metabolites; |
| Boiling Point | N/A |
| Applications | Harmine is a natural β-carboline alkaloid and a CNS stimulant (1,2). Harmine has been shown to be a potent and selective inhibitor of dual specificity tyrosine phosphorylation regulated kinase 1A (DYRK1A) (3). DYRK1A is a potential therapeutic target for treating diabetes, Down Syndrome, and HIV (4). |
| References | - (1) DiStefano, S., et al.: J. Pharmacol. Exp. Ther., 174, 456 (1970)
- (2) Dos Santos, R. G. and Hallak, J. E. J Psychoactive Drugs. 5,1 (2016)
- (3) Atteya, R., et al.: Mech Ageing Dev. 6, S0047 (2016)
- (4) Bol, S. M., et al.: PLoS One. 6, e17190 (2011)
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