U-104;≥98% (HPLC)

别名:U104;U 104;4-(3-(4-氟苯基)脲基)苯磺酰胺;4-[[[(4-Fluorophenyl)amino]carbonyl]amino]-benzenesulfonamide, NSC 213841

Empirical Formula (Hill Notation): C13H12FN3O3S CAS号: 178606-66-1 分子量: 309.32 MDL编号: MFCD00159265 PubChem化学物质编号: 329825375 NACRES: NA.77
制造商品牌: 西格玛 Sigma-Aldrich
货号(SKU): SML0374
CAS号: 178606-66-1
MDL号: MFCD00159265
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¥1,044.12

说明

生化/生理作用

U-104 is an inhibitor of CA IX that binds only to CA IX under hypoxic conditions in vivo. The binding results in significant inhibition of tumor growth and metastasis formation in both spontaneous and experimental models of metastasis. U-104 reduces the medium acidity by inhibiting the catalytic activity of the CA IX. It binds specifically only to hypoxic cells expressing CA IX.
 
 

属性

质量水平

检测方案

≥98% (HPLC)

形式

powder

颜色

white to beige

溶解性

DMSO: >15 mg/mL

储存温度

2-8°C

SMILES string

O=C(NC1=CC=C(S(N)(=O)=O)C=C1)NC2=CC=C(F)C=C2

InChI

1S/C13H12FN3O3S/c14-9-1-3-10(4-2-9)16-13(18)17-11-5-7-12(8-6-11)21(15,19)20/h1-8H,(H2,15,19,20)(H2,16,17,18)

InChI key

YJQZNWPYLCNRLP-UHFFFAOYSA-N

 

安全信息

储存分类代码

11 - Combustible Solids

WGK

WGK 3

商品规格
属性名称属性值
储存温度 Storage temp.2-8°C冷藏
全球实时库存 Availability √美国St. Louis ≥ 20 | 欧洲Eur. ≥ 16 | 東京Tokyo ≥ 5 | 香港与北京 ≥ 20