TMI-1，≥98% (HPLC)

别名：WAY-171318, TMI 1；4-[[4-(2-丁炔氧基)苯基]磺酰基]-N-羟基-2,2-二甲基-(3S)硫代吗啉甲酰胺；4-4-(2-Butynyloxy)phenylsulfonyl-N-hydroxy-2,2-dimethyl-(3S)thiomorpholinecarboxamide

Empirical Formula (Hill Notation): C17H22N2O5S2 CAS号: 287403-39-8 分子量: 398.50 PubChem化学物质编号: 329823847

制造商品牌: 西格玛 Sigma-Aldrich

货号（SKU）: PZ0336

CAS号: 287403-39-8

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目录价.SKU-Variant

5mg
25mg [+¥3,304.12]

¥1,591.58

数量:

说明

生化/生理作用

TMI-1 (WAY-171318) is potent inhibitor of disintegrin metalloenzyme 17 (ADAM17) also known as the tumor necrosis factor-α (TNF-α) converting enzyme (TACE), and matrix metalloprotease (MMP). TMI-1 potently inhibits LPS-induced TNF-α secretion in human primary monocytes, and human whole blood. TMI-1 selectively induces caspase-dependent apoptosis in triple negative (TN) and ERBB2-overexpressing breast tumor cell lines.

其他说明

This compound was developed by Pfizer for Cytokines & Growth Factors research. To learn more about Sigma′s partnership with Pfizer and view other authentic, high-quality Pfizer compounds, visit sigma.com/bsm-pfizer.

法律信息

Sold for research purposes under agreement from Pfizer Inc.

Pfizer is a registered trademark of Pfizer, Inc.

属性

质量水平

100

检测方案

≥98% (HPLC)

形式

powder

manufacturer/tradename

Pfizer^®

颜色

white to beige

溶解性

DMSO: 25 mg/mL, clear

创始人

Pfizer

储存温度

room temp

SMILES string

O=S(N1[C@@H](C(NO)=O)C(C)(C)SCC1)(C2=CC=C(OCC#CC)C=C2)=O

InChI

1S/C17H22N2O5S2/c1-4-5-11-24-13-6-8-14(9-7-13)26(22,23)19-10-12-25-17(2,3)15(19)16(20)18-21/h6-9,15,21H,10-12H2,1-3H3,(H,18,20)/t15-/m0/s1

InChI key

CVZIHNYAZLXRRS-HNNXBMFYSA-N

安全信息

储存分类代码

13 - Non Combustible Solids

WGK

WGK 3

商品规格

属性名称	属性值
储存温度 Storage temp.	常温阴凉避光
全球实时库存 Availability √	美国St. Louis ≥ 20 \| 欧洲Eur. ≥ 16 \| 東京Tokyo ≥ 5 \| 香港与北京 ≥ 20

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