TH-257，≥98% (HPLC)

图片 TH-257，≥98% (HPLC)
别名：N-丁基-4-[(苯基氨基)磺酰基]-N-(苯基甲基)苯甲酰胺，N-苄基-N-丁基-4-(N-苯基氨磺酰基)苯甲酰胺；N-Butyl-4-[(phenylamino)sulfonyl]-N-(phenylmethyl)benzamide, N-Benzyl-N-butyl-4-(N-phenylsulfamoyl)benzamide

Empirical Formula (Hill Notation): C24H26N2O3S 分子量: 422.54
制造商品牌: 西格玛 Sigma-Aldrich
货号（SKU）: SML2275
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¥819.25

说明

生化/生理作用

TH-257 is a potent, type III allosteric LIM-kinase (LIMK1 & LIMK2) inhibitor (LIMK1/2 IC50 in nM = 48/29 by cell-free kinase assay and 250/150 by live cell NanoBRET assay using respective transfectants) that targets LIMK1/2 DFG-out conformation in a non-ATP-competitive manner and exhibits no significant off-target activity by KINOMEscan assay at 1 μM. TH-263 is a structure analog and the recommended negative control for TH-257. For characterization details of TH-257, please visit the TH-257 probe summary on the Structural Genomics Consortium (SGC) website.

TH-263 is the negative control for the active probe, TH-257. TH-263 is available from Sigma. To learn more about and purchase TH-263, click here.
To learn about other SGC chemical probes, visit sigma.com/sgc
 

特点和优势

TH-257 is a chemical probe available through a partnership with the Structural Genomics Consortium (SGC). To learn more and view other SGC epigenetic probes, visit sigma.com/SGC.
 
 

属性

测定

≥98% (HPLC)

形式

powder

颜色

white to beige

溶解性

DMSO: 2 mg/mL, clear

储存温度

2-8°C

SMILES string

O=C(C1=CC=C(C=C1)S(NC2=CC=CC=C2)(=O)=O)N(CC3=CC=CC=C3)CCCC

 

安全信息

储存分类代码

13 - Non Combustible Solids

WGK

WGK 3

商品规格
属性名称属性值
储存温度 Storage temp.2-8°C冷藏
全球实时库存 Availability √美国St. Louis ≥ 20 | 欧洲Eur. ≥ 16 | 東京Tokyo ≥ 5 | 香港与北京 ≥ 20
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