It initiates the formation of death-inducing signal complex (DISC) by recruiting fas-associated death domain (FADD) and caspases to its cytoplasmic death domain (DD). In human lung cancer cells, parthenolide (PTL) induces extrinsic apoptosis by up-regulating TNFRSF10B.
[1] Deregulation of this gene results in metastasis, invasion and migration of tumor cells. Mutation leads to loss of p arm in this gene which is frequently the case in head and neck tumors.
[2] In a breast cancer xenograft mouse model, DR5 facilitates skeletal metastasis.
[3] In prostate carcinoma (PCa) and prostatic intraepithelial neoplasia (PIN), the expression of DR5 is lower in higher grade tumors.
[4]