ST034307,≥98% (HPLC)

别名:6-氯-2-(三氯甲基)-4H-苯并吡喃-4-酮;6-Chloro-2-(trichloromethyl)-4H-1-benzopyran-4-one, 6-Chloro-2-(trichloromethyl)chromen-4-one

Empirical Formula (Hill Notation): C10H4Cl4O2 CAS号: 133406-29-8 分子量: 297.95 MDL编号: MFCD00760793 NACRES: NA.77
制造商品牌: 西格玛 Sigma-Aldrich
货号(SKU): SML2109
CAS号: 133406-29-8
MDL号: MFCD00760793
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¥1,000.05

说明

生化/生理作用

ST034307 is a selective inhibitor of adenylyl cyclase 1 (AC1) with analgesic activity. Adenylyl cyclase 1 has been shown to be a potential target for treating pain and reducing the dependency on opioids, but it has been difficult to inhibit AC1 selectively without also inhibiting other isoforms vital to physiological functions. ST034307 is selective for AC1 over all eight other adenylyl cyclase isoforms. It inhibited AC1 and reduced cAMP, while leaving AC8 unaffected and was shown to reduce pain in a mouse inflammatory pain model.
 
 

属性

检测方案

≥98% (HPLC)

形式

powder

颜色

faint green to dark gray

溶解性

DMSO: 2 mg/mL, clear (warmed)

储存温度

−20°C

SMILES string

ClC(Cl)(Cl)C1=CC(C2=CC(Cl)=CC=C2O1)=O

 

安全信息

储存分类代码

13 - Non Combustible Solids

WGK

WGK 3

商品规格
属性名称属性值
储存温度 Storage temp.-20°C低温冷冻
全球实时库存 Availability √美国St. Louis ≥ 50 | 欧洲Eur. ≥ 12 | 東京Tokyo ≥ 20 | 香港与北京 ≥ 50