SMI-4a,≥98% (HPLC)

别名:(Z)-5-(3-(三氟甲基)亚苄基)噻唑烷-2,4-二酮;(5Z)-5-[[3-(Trifluoromethyl)phenyl]methylene]-2,4-thiazolidinedione, (Z)-5-(3-Trifluoromethylbenzylidene)thiazolidine-2,4-dione

Empirical Formula (Hill Notation): C11H6F3NO2S CAS号: 438190-29-5 分子量: 273.23 MDL编号: MFCD01152003 PubChem化学物质编号: 329825328
制造商品牌: 西格玛 Sigma-Aldrich
货号(SKU): SML0323
CAS号: 438190-29-5
MDL号: MFCD01152003
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¥976.00

说明

生化/生理作用

SMI-4a is a selective ATP-competitive Pim-1 kinase inhibitor with an IC50 of 21 nM for Pim-1 compared to an IC50 of 100 nM for Pim-2 and with little or no activity against a panel of 50 other kinases tested. SMI-4a has been found to inhibit prostate cancer cell growth and induce G1 phase cell-cycle arrest in precursor T-cell lymphoblastic leukemia/lymphoma cell lines.
 
 

属性

质量水平

检测方案

≥98% (HPLC)

形式

powder

颜色

white to beige

溶解性

DMSO: >10 mg/mL

储存温度

2-8°C

SMILES string

FC(F)(F)c1cccc(\C=C2/SC(=O)NC2=O)c1

InChI

1S/C11H6F3NO2S/c12-11(13,14)7-3-1-2-6(4-7)5-8-9(16)15-10(17)18-8/h1-5H,(H,15,16,17)/b8-5-

InChI key

NGJLOFCOEOHFKQ-YVMONPNESA-N

 

安全信息

象形图

Exclamation mark

警示用语:

Warning

危险声明

危险分类

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

靶器官

Respiratory system

储存分类代码

11 - Combustible Solids

WGK

WGK 3

商品规格
属性名称属性值
储存温度 Storage temp.2-8°C冷藏
全球实时库存 Availability √美国St. Louis ≥ 50 | 欧洲Eur. ≥ 12 | 東京Tokyo ≥ 20 | 香港与北京 ≥ 50