SGC8158，≥98% (HPLC)

图片 SGC8158，≥98% (HPLC)
别名：5'-S-[4-[(4'-氯联苯-3-基甲基)氨基]丁基]-5'-硫腺苷；5′-S-[4-[(4′-Chlorobiphenyl-3-ylmethyl)amino]butyl]-5′-thioadenosine

Empirical Formula (Hill Notation): C27H31ClN6O3S 分子量: 555.09
制造商品牌: 西格玛 Sigma-Aldrich
货号（SKU）: SML2340
签订合同 √ 正规发票 √ 技术支持 √ 质量保障 √ 全程可追溯 √
¥2,549.13

说明

生化/生理作用

SGC8158 isthe active component produced by cell reductases from the prodrug, SGC3027, a selective and cell-active inhibitor of protein arginine N-methyltransferase (PRMT7). SGC8158 was shown to inhibit PRMT7 with an IC50 value < 2.5 nM for methylation of H2B (23-37) and greater than 40-fold selectivity over other histone methyltransferases and non-epigenetic targets. SGC3027 inhibited the methylation of HSP70 In cellular assays using C2C12 cells with an IC50 value of 1.3 microM. The closely related SGC3027N is significantly less active in the cellular assay, and is a control compound for cellular studies.
 
 

属性

质量水平

100

测定

≥98% (HPLC)

形式

powder

颜色

white to beige

溶解性

DMSO: 2 mg/mL, clear

储存温度

2-8°C

SMILES string

ClC(C=C1)=CC=C1C2=CC(CNCCCCSC[C@H]3O[C@@H](N(C=N4)C5=C4C(N)=NC=N5)[C@H](O)[C@@H]3O)=CC=C2

 

安全信息

储存分类代码

11 - Combustible Solids

WGK

WGK 3

商品规格
属性名称属性值
储存温度 Storage temp.2-8°C冷藏
全球实时库存 Availability √美国St. Louis ≥ 20 | 欧洲Eur. ≥ 16 | 東京Tokyo ≥ 5 | 香港与北京 ≥ 20
商品分类
热门标签
更多