SC-236,≥98% (HPLC)

别名:SC-58236, 4-5-(4-Chlorophenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl-benzenesulfonamide;4-(5-(4-氯苯基)-3-三氟甲基)-1H-吡唑-1-基)苯磺酰胺

Empirical Formula (Hill Notation): C16H11ClF3N3O2S CAS号: 170569-86-5 分子量: 401.79 MDL编号: MFCD00941297 PubChem化学物质编号: 329823698 NACRES: NA.77
制造商品牌: 西格玛 Sigma-Aldrich
货号(SKU): PZ0106
CAS号: 170569-86-5
MDL号: MFCD00941297
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¥1,163.90

说明

应用

SC-236 has been used as a COX-2 inhibitor to study its effects on the mechano-reflex in rats.[1]
 

生化/生理作用

SC-236 exhibits anti-tumor activity in gastric cancer cells by modulating activator protein-1 (AP-1) expression and by blocking the anchorage-independent cell growth.[2] It also exhibits a protective effect against cartilage damage by minimizing the inflammation and pain in osteoarthritis. It is also reported to treat allergic inflammation.[3]
SC-236 is a cyclooxygenase-2 (COX-2) inhibitor.
 

其他说明

This compound was developed by Pfizer for Lipid Signaling research. To learn more about Sigma′s partnership with Pfizer and view other authentic, high-quality Pfizer compounds, visit sigma.com/bsm-pfizer.
To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.
 

法律信息

Sold for research purposes under agreement from Pfizer Inc.
Pfizer is a registered trademark of Pfizer, Inc.
 
 

属性

测定

≥98% (HPLC)

形式

powder

mfr. no.

Pfizer®

颜色

white to off-white

溶解性

DMSO: >20 mg/mL

创始人

Pfizer

储存温度

2-8°C

SMILES string

NS(=O)(=O)c1ccc(cc1)-n2nc(cc2-c3ccc(Cl)cc3)C(F)(F)F

InChI

1S/C16H11ClF3N3O2S/c17-11-3-1-10(2-4-11)14-9-15(16(18,19)20)22-23(14)12-5-7-13(8-6-12)26(21,24)25/h1-9H,(H2,21,24,25)

InChI key

NSQNZEUFHPTJME-UHFFFAOYSA-N

 

安全信息

象形图

Skull and crossbones

警示用语:

Danger

危险声明

危险分类

Acute Tox. 3 Oral

储存分类代码

6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3 

商品规格
属性名称属性值
储存温度 Storage temp.2-8°C冷藏
全球实时库存 Availability √美国St. Louis ≥ 20 | 欧洲Eur. ≥ 16 | 東京Tokyo ≥ 5 | 香港与北京 ≥ 20