SB-222200，≥98% (HPLC), solid

别名：SB222200；SB 222200；(S)-3-甲基-2-苯基-N-(1-苯基丙基)-4-喹啉甲酰胺；(S)-3-Methyl-2-phenyl-N-(1-phenylpropyl)-4-quinolinecarboxamide

Empirical Formula (Hill Notation): C26H24N2O CAS号: 174635-69-9 分子量: 380.48 MDL编号: MFCD00944072 PubChem化学物质编号: 24278254 NACRES: NA.77

制造商品牌: 西格玛 Sigma-Aldrich

货号（SKU）: S5192

CAS号: 174635-69-9

MDL号: MFCD00944072

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目录价.SKU-Variant

10mg
50mg [+¥7,480.60]
250mg [+¥21,035.72]

¥2,565.10

数量:

说明

应用

The pharmacodynamics profile of SB 222200 enables its use as a tool to study physiological and pathophysiological roles of NK-3 receptor in CNS-modulated behaviors.

生化/生理作用

SB 222200 is a 2-phenyl-4-quinolinecarboxamides and a selective, reversible and competitive antagonist of human NK-3 receptor that effectively crosses the blood-brain barrier. It inhibits the NK-3 receptor-induced miosis or pupil constriction in conscious rabbits.^1,2

Non-peptide NK₃ tachykinin receptor antagonist.

特点和优势

This compound was developed by GlaxoSmithKline. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

法律信息

Sold for research purposes under agreement from GlaxoSmithKline

属性

质量水平

100

测定

≥98% (HPLC)

形式

solid

颜色

light yellow

溶解性

DMSO: soluble ~28 mg/mL
H₂O: insoluble

创始人

GlaxoSmithKline

储存温度

2-8°C

SMILES string

CC[C@H](NC(=O)c1c(C)c(nc2ccccc12)-c3ccccc3)c4ccccc4

InChI

1S/C26H24N2O/c1-3-22(19-12-6-4-7-13-19)28-26(29)24-18(2)25(20-14-8-5-9-15-20)27-23-17-11-10-16-21(23)24/h4-17,22H,3H2,1-2H3,(H,28,29)/t22-/m0/s1

InChI key

MQNYRKWJSMQECI-QFIPXVFZSA-N

Gene Information

human ... TACR2(6865), TACR3(6870)

安全信息

储存分类代码

13 - Non Combustible Solids

WGK

WGK 3

个人防护装备

Eyeshields, Gloves, type N95 (US)

商品规格

属性名称	属性值
储存温度 Storage temp.	2-8°C冷藏
全球实时库存 Availability √	美国St. Louis ≥ 20 \| 欧洲Eur. ≥ 16 \| 東京Tokyo ≥ 5 \| 香港与北京 ≥ 20

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