PF-6422899，≥98% (HPLC)

图片 PF-6422899，≥98% (HPLC)
别名：PF6422899；PF 6422899；N-[4-[(3-氯-4-氟苯基)氨基]-7-(2-丙炔-1-基氧基)-6-喹唑啉基]-2-丙烯酰胺；N-4-(3-Chloro-4-fluorophenyl)amino-7-(2-propyn-1-yloxy)-6-quinazolinyl-2-propenamide

Empirical Formula (Hill Notation): C20H14ClFN4O2 CAS号: 1621002-23-0 分子量: 396.80 MDL编号: MFCD28386019 PubChem化学物质编号: 329823788 NACRES: NA.77
制造商品牌: 西格玛 Sigma-Aldrich
货号（SKU）: PZ0241
CAS号: 1621002-23-0
MDL号: MFCD28386019
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¥1,591.58

说明

生化/生理作用

PF-6422899 is an alkynylated derivative of PF-6274484; irreversible inhibitor of EGFR kinase activity. PF-6422899 binds covalently to active-site cysteine residues in the ATP binding pocket of EGFR.
 

其他说明

This compound was developed by Pfizer for Kinase Phosphatase Biology research. To learn more about Sigma′s partnership with Pfizer and view other authentic, high-quality Pfizer compounds, visit sigma.com/bsm-pfizer.
To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.
 

法律信息

Sold for research purposes under agreement from Pfizer Inc.
Pfizer is a registered trademark of Pfizer, Inc.
 
 

属性

质量水平

100

测定

≥98% (HPLC)

形式

powder

mfr. no.

Pfizer®

颜色

white to beige

溶解性

DMSO: 5 mg/mL, clear (warmed)

创始人

Pfizer

储存温度

room temp

SMILES string

FC(C=C1)=C(Cl)C=C1NC2=NC=NC3=CC(OCC#C)=C(NC(C=C)=O)C=C32

InChI

1S/C20H14ClFN4O2/c1-3-7-28-18-10-16-13(9-17(18)26-19(27)4-2)20(24-11-23-16)25-12-5-6-15(22)14(21)8-12/h1,4-6,8-11H,2,7H2,(H,26,27)(H,23,24,25)

InChI key

AZLXGJFHSLQCPV-UHFFFAOYSA-N

 

安全信息

象形图

Exclamation mark
GHS07

警示用语：

Warning

危险声明

H315 - H319 - H335

危险分类

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

靶器官

Respiratory system

储存分类代码

11 - Combustible Solids

WGK

WGK 3

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储存温度 Storage temp.常温阴凉避光
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