PF-562271，≥98% (HPLC)

图片 PF-562271，≥98% (HPLC)
别名：PF562271；PF-00562271；N-(3-(((2-((2,3-二氢-2-氧代-1H-吲哚-5-基）氨基)-5-三氟甲基-4-嘧啶基氨基)甲基)-2-吡啶基)-N-甲基甲磺酰胺苯磺酸酯；N-(3-(((2-((2,3-Dihydro-2-oxo-1H-indol-5-yl)amino)-5- (trifluoromethyl)-4-pyrimidinyl)amino)methyl)-2-pyridinyl)-N-methyl-methanesulfonamide benzenesulfonate, PF 562271, PF-562271

Empirical Formula (Hill Notation): C21H20F3N7O3S · C6H6O3S CAS号: 939791-38-5 分子量: 665.66 MDL编号: MFCD14105612 NACRES: NA.77
制造商品牌: 西格玛 Sigma-Aldrich
货号（SKU）: PZ0387
CAS号: 939791-38-5
MDL号: MFCD14105612
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¥1,689.40

说明

应用

PF-562,271 has been used as a focal adhesion kinase (FAK) inhibitor to study its effects on the S100A9-induced tumor cell invasion in prostate cancer cell lines.[1] It has also been used to study its effects on syndecan-1 (SDC-1) knockdown-induced upregulation of early growth regulator 1 (EGR1) in colon cancer cells.[2]
 

生化/生理作用

PF-562,271 is a potent, ATP-competitive, reversible and selective inhibitor of FAK and Pyk2. PF-562,271 inhibits FAK phosphorylation in vivo.
 

法律信息

Sold for research purposes under agreement from Pfizer Inc.
Pfizer is a registered trademark of Pfizer, Inc.
 
 

属性

测定

≥98% (HPLC)

形式

powder

mfr. no.

Pfizer®

颜色

white to brown

溶解性

DMSO: 2 mg/mL, clear

创始人

Pfizer

储存温度

2-8°C

SMILES string

CN(S(=O)(C)=O)C1=NC=CC=C1CNC2=C(C(F)(F)F)C=NC(NC3=CC4=C(C=C3)NC(C4)=O)=N2.O=S(C5=CC=CC=C5)(O)=O

 

安全信息

储存分类代码

11 - Combustible Solids

WGK

WGK 3

商品规格
属性名称属性值
储存温度 Storage temp.2-8°C冷藏
全球实时库存 Availability √美国St. Louis ≥ 20 | 欧洲Eur. ≥ 16 | 東京Tokyo ≥ 5 | 香港与北京 ≥ 20
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