PF-05212384 [PKI-587]，≥98% (HPLC)

图片 PF-05212384 [PKI-587]，≥98% (HPLC)
别名：Gedatolisib；1-(4-(4-(二甲基氨基）哌啶-1-基)羰基)苯基)-3-(4-(4,6-二吗啉-4-基-1,3,5-三嗪-2-基)苯基)脲；1-(4-((4-(Dimethylamino)piperidin-1-yl)carbonyl)phenyl)-3-(4-(4,6-dimorpholin-4-yl-1,3,5-triazin-2-yl)phenyl)urea

Empirical Formula (Hill Notation): C32H41N9O4 CAS号: 1197160-78-3 分子量: 615.73
制造商品牌: 西格玛 Sigma-Aldrich
货号（SKU）: PZ0281
CAS号: 1197160-78-3
MDL号: MFCD16875679
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¥1,081.41

说明

生化/生理作用

PF-05212384, also known as PKI-587 and Gedatolisib, is a dual phosphatidylinositol-3-kinase (PI3K) / mammalian target of rapamycin (mTOR) inhibitor. PKI-587 potently inhibited class I PI3Ks (IC50 vs PI3K-α = 0.4 nM), PI3K-α mutants, and mTOR. PF-05212384 inhibited growth of 50 diverse human tumor cell lines at IC50s <100 nM and has been in clinical trials in patients with advanced solid tumors. PF-05212384 has also been found to sensitize cells to radiation.
 

其他说明

This compound was developed by Pfizer for Kinase Phosphatase Biology research. To learn more about Sigma′s partnership with Pfizer and view other authentic, high-quality Pfizer compounds, visit sigma.com/bsm-pfizer.
To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.
 

法律信息

Sold for research purposes under agreement from Pfizer Inc.
Pfizer is a registered trademark of Pfizer, Inc.
 
 

属性

质量水平

100

检测方案

≥98% (HPLC)

形式

powder

manufacturer/tradename

Pfizer®

颜色

white to beige

溶解性

DMSO: 0.5 mg/mL, clear (warmed)

创始人

Pfizer

储存温度

room temp

InChI

1S/C32H41N9O4/c1-38(2)27-11-13-39(14-12-27)29(42)24-5-9-26(10-6-24)34-32(43)33-25-7-3-23(4-8-25)28-35-30(40-15-19-44-20-16-40)37-31(36-28)41-17-21-45-22-18-41/h3-10,27H,11-22H2,1-2H3,(H2,33,34,43)

InChI key

DWZAEMINVBZMHQ-UHFFFAOYSA-N

 

安全信息

储存分类代码

13 - Non Combustible Solids

WGK

WGK 3

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储存温度 Storage temp.常温阴凉避光
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