PF-04691502，≥98% (HPLC)

图片 PF-04691502，≥98% (HPLC)
别名：PF04691502；PF-4691502, 2-Amino-8-trans-4-(2-hydroxyethoxy)cyclohexyl-6-(6-methoxy-3-pyridinyl)-4-methyl-pyrido2,3-dpyrimidin-7(8H)-one, PF04691502

Empirical Formula (Hill Notation): C22H27N5O4 CAS号: 1013101-36-4 分子量: 425.48 PubChem化学物质编号: 329823786
制造商品牌: 西格玛 Sigma-Aldrich
货号（SKU）: PZ0235
CAS号: 1013101-36-4
MDL号: MFCD18782794
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¥1,091.58

说明

生化/生理作用

PF-04691502 is a potent dual mTOR/PI3K inhibitor with Ki values of 1.6, 1.8, 1.9, 2.1 and 16 nM for human PI 3-K δ, α, β, γ, and mTOR, respectively, with no significant inhibitory activity at more than 80 other protein kinases, including PI 3-K downstream kinases, and MAPK family members. PF-04691502 showed antitumor activity in several non-small cell lung carcer (NSCLC) xenografts and ovarian cancer cell lines. PF-04691502 is currently in clinical trials.
 

其他说明

This compound was developed by Pfizer for Kinase Phosphatase Biology research. To learn more about Sigma′s partnership with Pfizer and view other authentic, high-quality Pfizer compounds, visit sigma.com/bsm-pfizer.
To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.
 

法律信息

Sold for research purposes under agreement from Pfizer Inc.
Pfizer is a registered trademark of Pfizer, Inc.
 
 

属性

质量水平

100

检测方案

≥98% (HPLC)

形式

powder

manufacturer/tradename

Pfizer®

颜色

white to yellow to light brown

溶解性

DMSO: 2 mg/mL, clear (warmed)

创始人

Pfizer

储存温度

room temp

SMILES string

CC1=C(C(N([C@H]2CC[C@H](OCCO)CC2)C3=O)=NC(N)=N1)C=C3C4=CN=C(OC)C=C4

InChI

1S/C22H27N5O4/c1-13-17-11-18(14-3-8-19(30-2)24-12-14)21(29)27(20(17)26-22(23)25-13)15-4-6-16(7-5-15)31-10-9-28/h3,8,11-12,15-16,28H,4-7,9-10H2,1-2H3,(H2,23,25,26)/t15-,16-

InChI key

XDLYKKIQACFMJG-WKILWMFISA-N

Gene Information

human ... MTOR(2475) , PIK3CA(5290) , PIK3CB(5291) , PIK3CD(5293) , PIK3CG(5294) , PIK3R1(5295) , PIK3R2(5296) , PIK3R3(8503) , PIK3R5(23533)

 

安全信息

储存分类代码

11 - Combustible Solids

WGK

WGK 3

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