PF-04620110,≥98% (HPLC)

别名:反式-4-[4-(4-氨基-7,8-二氢-5-氧代嘧啶并[5,4-F][1,4]氧杂卓-6(5H)-苯基]-环己烷乙酸;trans-4-4-(4-Amino-7,8-dihydro-5-oxopyrimido5,4-f1,4oxazepin-6(5H)-yl)phenyl-cyclohexaneacetic acid

Empirical Formula (Hill Notation): C21H24N4O4 CAS号: 1109276-89-2 分子量: 396.44 PubChem化学物质编号: 329823775 NACRES: NA.77
制造商品牌: 西格玛 Sigma-Aldrich
货号(SKU): PZ0207
CAS号: 1109276-89-2
MDL号: MFCD19443642
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¥1,152.60

说明

生化/生理作用

PF-04620110 is an orally active, selective and potent DGAT1 (Acyl-CoA:diacylglycerol acyltransferase 1) inhibitor that inhibits triacylglycerol synthesis in cells and in rodents.
PF-04620110 is known to regulate gut hormones.[1] Inhibition of DGAT1 might serve as a good approach for the treatment of obesity and type 2 diabetes.[2] DGAT1 inhibition might increase the oxidation of fatty acids, thus it is found to be protective against hepatic steatosis.[3]
 

其他说明

This compound was developed by Pfizer for Lipid Signaling research. To learn more about Sigma′s partnership with Pfizer and view other authentic, high-quality Pfizer compounds, visit sigma.com/bsm-pfizer.
To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.
 

法律信息

Sold for research purposes under agreement from Pfizer Inc.
Pfizer is a registered trademark of Pfizer, Inc.
 
 

属性

质量水平

100

测定

≥98% (HPLC)

形式

powder

mfr. no.

Pfizer®

颜色

white to beige

溶解性

DMSO: 10 mg/mL (clear solution)

创始人

Pfizer

储存温度

room temp

SMILES string

Nc1ncnc2OCCN(C(=O)c12)c3ccc(cc3)C@@H4CCC@H(CC4)CC(O)=O

InChI

1S/C21H24N4O4/c22-19-18-20(24-12-23-19)29-10-9-25(21(18)28)16-7-5-15(6-8-16)14-3-1-13(2-4-14)11-17(26)27/h5-8,12-14H,1-4,9-11H2,(H,26,27)(H2,22,23,24)/t13-,14-

InChI key

GEVVQZHMFVFGLN-HDJSIYSDSA-N

 

安全信息

象形图

Exclamation mark

警示用语:

Warning

危险声明

危险分类

Acute Tox. 4 Oral

储存分类代码

11 - Combustible Solids

WGK

WGK 3

商品规格
属性名称属性值
储存温度 Storage temp.常温阴凉避光
全球实时库存 Availability √美国St. Louis ≥ 20 | 欧洲Eur. ≥ 16 | 東京Tokyo ≥ 5 | 香港与北京 ≥ 20