PF-04457845，≥98% (HPLC)

别名：N-(3-哒嗪基)-4-(3-[5-三氟甲基-2-吡啶氧基]亚苄基)哒啶-1-甲酰胺；N-3-哒嗪基-4-[[3-[[[5-(三氟甲基)-2-吡啶基]氧基]苯基]亚甲基]-1-哒啶甲酰胺；PF04457845；N-3-Pyridazinyl-4-3-5-(trifluoromethyl)-2-pyridinyloxyphenylmethylene-1-piperidinecarboxamide, PF-4457845, N-(3-pyridazinyl)-4-(3-5-trifluoromethyl-2-pyridinyloxybenzylidene)piperidine-1-carboxamide

Empirical Formula (Hill Notation): C23H20F3N5O2 CAS号: 1020315-31-4 分子量: 455.43 MDL编号: MFCD18782721 PubChem化学物质编号: 329823758 NACRES: NA.77

制造商品牌: 西格玛 Sigma-Aldrich

货号（SKU）: PZ0184

CAS号: 1020315-31-4

MDL号: MFCD18782721

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目录价.SKU-Variant

5mg
25mg [+¥3,304.12]
100mg [+¥11,408.68]

¥1,091.58

数量:

说明

生化/生理作用

PF-04457845 is a potent, orally active, irreversible inhibitor of fatty acid amide hydrolase (FAAH), the principle enzyme involved in the degradation of the endocannabinoid anandamide. PF-04457845 is a covalent inhibitor that carbamylates FAAH′s serine nucleophile. It was shown to be both potent and selective against other serine hydrolases. It has an IC50 value of 7.2 nM for human FAAH. The endocannabinoid system is a target for therapeutic pain relief. In a rat model of inflammatory pain, PF-04457845 produced significant reduction of inflammatory pain with efficacy comparable to that of naproxen at 10 mg/kg.

其他说明

This compound was developed by Pfizer for Neuroscience research. To learn more about Sigma′s partnership with Pfizer and view other authentic, high-quality Pfizer compounds, visit sigma.com/bsm-pfizer.
To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

法律信息

Sold for research purposes under agreement from Pfizer Inc.

Pfizer is a registered trademark of Pfizer, Inc.

属性

质量水平

100

检测方案

≥98% (HPLC)

形式

powder

manufacturer/tradename

Pfizer^®

颜色

white to beige

溶解性

DMSO: 20 mg/mL

创始人

Pfizer

储存温度

room temp

SMILES string

O=C(NC1=NN=CC=C1)N(CC2)CCC2=CC3=CC=CC(OC4=NC=C(C(F)(F)F)C=C4)=C3

InChI

1S/C23H20F3N5O2/c24-23(25,26)18-6-7-21(27-15-18)33-19-4-1-3-17(14-19)13-16-8-11-31(12-9-16)22(32)29-20-5-2-10-28-30-20/h1-7,10,13-15H,8-9,11-12H2,(H,29,30,32)

InChI key

BATCTBJIJJEPHM-UHFFFAOYSA-N

安全信息

储存分类代码

13 - Non Combustible Solids

WGK

WGK 3

商品规格

属性名称	属性值
储存温度 Storage temp.	常温阴凉避光
全球实时库存 Availability √	美国St. Louis ≥ 20 \| 欧洲Eur. ≥ 16 \| 東京Tokyo ≥ 5 \| 香港与北京 ≥ 20

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