N6-甲基腺苷，N6-Methyladenosine

图片 N6-甲基腺苷，N6-Methyladenosine
CasNo：1867-73-8；MDL:MFCD00005739；分子式:C11H15N5O4；分子量:281.27
制造商品牌: 加拿大TRC
货号（SKU）: M275895
CAS号: 1867-73-8
MDL号: MFCD00005739
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Product Description

Catalogue NumberM275895
Chemical NameN6-Methyladenosine
Synonyms6-Methyladenosine; N-methyladenosine; 6-Methylamino-9-β-D-ribofuranosylpurine; 6-Methylaminopurine D-riboside; 6-Methylaminopurine ribonucleoside; 6-Methylaminopurine riboside; 9-β-D-Ribofuranosyl-N6-methylaminopurine; N-Methyladenosine; N6-Methyladenosine; NSC 29409;
CAS Number1867-73-8
Alternate CAS #Labelled:139896-43-8;
Molecular FormulaC₁₁H₁₅N₅O₄
AppearanceWhite to Off-White Solid
Melting Point>147°C (dec.)
Molecular Weight281.27
StorageHygroscopic, Refrigerator, under inert atmosphere
SolubilityDMSO (Slightly), Methanol (Slightly, Heated), Water (Slightly, Heated)
StabilityHygroscopic
CategoryStandards; Pharmaceutical/API Drug Impurities/Metabolites;
ApplicationsN6-Methyladenosine is the most common internal modification of eukaryotic mRNA. The result of this modification is specifically recognized mRNA in the cytoplasm which regulates mRNA stability. N6-Methyladenosine is made when a protein complex containin the writer enzyme METTL3 adds a methyl group to adenosine. Two different eraser enzymes ALKBH5 and FTO can remove a methyl group to turn m6A bach into adenosine.
ReferencesMiura, G. et al.: Nat. Chem. Biol., 11, 903 (2015); Deng, X. et al.: Nucl. Acids Res., 43, 6557 (2015); Chem. and Eng. News, p.35, Feb. 18, 2019
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储存温度 Storage temp.2-8°C冷藏
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