General description
一种高亲和力的RAGE特异性阻断剂，可抑制APP（SW／0）转基因小鼠模型中淀粉样蛋白β与RAGE、神经损伤和炎症的结合。
FPS-ZM1 is a high-affinity RAGE-specific blocker that inhibits amyloid-β binding to RAGE, neurological damage and inflammation in the APP(sw/0) transgenic mouse model of AD. FPS-ZM1 is not toxic to mice and can easily cross the blood-brain barrier. AGEs administration induced an-regulation of Abeta production, inflammation, and oxidative stress, and an increased escape latency of rats in the Morris water maze test, all of these are significantly reduced by FPS-ZM1 treatment. FPS-ZM1 might be a novel therapeutic agent to treat AD patients.
FPS-ZM1是一种高亲和力的RAGE特异性阻滞剂，可在AD（sw / 0）转基因小鼠AD模型中抑制淀粉样β与RAGE的结合，神经损伤和炎症。 FPS-ZM1对小鼠无毒，可以轻松穿越血脑屏障。 在莫里斯水迷宫测试中，AGEs的使用诱导了Abeta产生，炎症和氧化应激的调节，并增加了大鼠的逃逸潜伏期，所有这些都通过FPS-ZM1处理得以显着降低。 FPS-ZM1可能是治疗AD患者的新型治疗剂。
Properties
| Iupac Name： | N-benzyl-4-chloro-N-cyclohexylbenzamide |
| Inchi Code | 1S/C20H22ClNO/c21-18-13-11-17(12-14-18)20(23)22(19-9-5-2-6-10-19)15-16-7-3-1-4-8-16/h1,3-4,7-8,11-14,19H,2,5-6,9-10,15H2 |
| Inchi Key | XDFKWGIBQMHSOH-UHFFFAOYSA-N |
安全信息
