Fmoc-S-乙酰氨甲基-L-半胱氨酸，Fmoc-Cys(Acm)-OH；Novabiochem®, ≥98%

The side-chain Acm group is stable to TFA but can be removed with Hg(II) ^[1] or Ag(I) ^[2] to give cysteinyl peptides, or oxidatively with Tl(III) ^[3] or I₂ ^[4] to generate cystinyl peptides.

Associated Protocols and Technical Articles
Cleavage and Deprotection Protocols for Fmoc SPPS
Fmoc SPPS of Cysteine-Containing Peptides

Literature references

^[1] D. F. Veber, et al. (1972) J. Am. Chem. Soc., 94, 5456.
^[2] M. Yoshida, et al. (1990) Chem. Pharm. Bull., 38, 273.
^[3] N. Fujii, et al. (1987) Chem. Pharm. Bull., 36, 2339.
^[4] B. Kamber, et al. (1980) Helv. Chim. Acta, 63, 899.

 

Replaces: 04-12-1014

 

Color (visual): white to slight yellow to beige
Appearance of substance (visual): powder
Identity (IR): passes test
Enantiomeric purity: ≥ 99.5 % (a/a)
Purity (TLC(011B)): ≥ 98 %
Purity (TLC(0811)): ≥ 98 %
Assay (HPLC, area%): ≥ 99.0 % (a/a)
Solubility (25 mmole in 50 ml DMF): clearly soluble
UV/VIS (E(450 bis 600 nm)): ≤ 50 mAU
Assay (acidimetric): ≥ 96.0 %
Water (K. F.): ≤ 5.00 %

To see the solvent systems used for TLC of Novabiochem^® products please click here.

 

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