CYP3cide，≥98% (HPLC)

图片 CYP3cide，≥98% (HPLC)
别名：PF-04981517；PF-4981517；1-甲基-3-[1-甲基-5-（4-甲基苯基）-1H-吡唑-4-基]-4-[（3S）-3-哌啶-1-基吡咯烷-1-基]-1H-吡唑并[3，4-d]嘧啶；1-Methyl-3-1-methyl-5-(4-methylphenyl)-1H-pyrazol-4-yl-4-(3S)-3-piperidin-1-ylpyrrolidin-1-yl-1H-pyrazolo3,4-dpyrimidine

Empirical Formula (Hill Notation): C26H32N8 分子量: 456.59 MDL编号: MFCD22417344 PubChem化学物质编号: 329823769 NACRES: NA.77
制造商品牌: 西格玛 Sigma-Aldrich
货号（SKU）: PZ0195
CAS号: 1390637-82-7
MDL号: MFCD22417344
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说明

生化/生理作用

CYP3cide is a mechanism-based inhibitor of cytochrome P4503A4 that can be used to distinguish the contributions of CYP3A4 versus CYP3A5 on drug metabolism. The IC50 values for inhibition of Midazolam 1′-Hydroxylase activity of recombinant CYP3A4 and CYP3A5 by CYP3cide are 0.3 and 17 mM, respectively.
 

特点和优势

This compound is a featured product for ADME Tox research. Click here to discover more featured ADME Tox products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
 

其他说明

This compound was developed by Pfizer for ADME/Tox research. To learn more about Sigma′s partnership with Pfizer and view other authentic, high-quality Pfizer compounds, visit sigma.com/bsm-pfizer.

To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.
 

法律信息

Sold for research purposes under agreement from Pfizer Inc.
Pfizer is a registered trademark of Pfizer, Inc.
 
 

属性

质量水平

100

检测方案

≥98% (HPLC)

形式

powder

manufacturer/tradename

Pfizer®

颜色

white to beige

溶解性

DMSO: >10 mg/mL (warmed)

创始人

Pfizer

储存温度

room temp

SMILES string

Cc1ccc(cc1)-c2c(cnn2C)-c3nn(C)c4ncnc(N5CC[C@@H](C5)N6CCCCC6)c34

InChI

1S/C26H32N8/c1-18-7-9-19(10-8-18)24-21(15-29-31(24)2)23-22-25(32(3)30-23)27-17-28-26(22)34-14-11-20(16-34)33-12-5-4-6-13-33/h7-10,15,17,20H,4-6,11-14,16H2,1-3H3/t20-/m0/s1

InChI key

WDWIMDKOXZZYHH-FQEVSTJZSA-N

 

安全信息

储存分类代码

11 - Combustible Solids

WGK

WGK 3

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