CP724714，≥98% (HPLC)

图片 CP724714，≥98% (HPLC)
别名：CP-724714；2-甲氧基-N-[3-[4-[[[3-甲基-4-[(6-甲基吡啶-3-基)氧基]苯基]氨基]喹唑啉-6-基]烯丙基]乙酰胺；2-甲氧基-N-[（2E）-3-[4-[[3-甲基-4-[[3-甲基-4-[（6-甲基-3-吡啶基）氧基]苯基]氨基]-6-喹唑啉基]-2-丙烯-1-基]乙酰胺；(E)-2-Methoxy-N-[3-[4-[[3-methyl-4-[(6-methylpyridin-3-yl)oxy]phenyl]amino]quinazolin-6-yl]allyl]ethanamide；2-Methoxy-N-[(2E)-3-[4-[[3-methyl-4-[(6-methyl-3-pyridinyl)oxy]phenyl]amino]-6-quinazolinyl]-2-propen-1-yl]-acetamide, CP-724,714

Empirical Formula (Hill Notation): C27H27N5O3 CAS号: 383432-38-0 分子量: 469.53 MDL编号: MFCD15144738 PubChem化学物质编号: 329823846
制造商品牌: 西格玛 Sigma-Aldrich
货号（SKU）: PZ0335
CAS号: 383432-38-0
MDL号: MFCD15144738
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¥1,091.58

说明

生化/生理作用

CP724714 is a potent and selective inhibitor of HER2/ErbB2 with an IC50 value of 10 nM. CP724714 is >640-fold selectivity against EGFR, and >1000-fold selective against InsR, IRG-1R, PDGFR, VEGFR2, Abl, Src, c-Met, JNK-2, JNK-3, ZAP-70, CDK-2 and CDK-5 in in vitro kinase assays. CP724714 had antiproliferative effects in a panel of human breast cancer cell lines.
 

其他说明

CP-724714 has been expertly reviewed and recommended by the Chemical Probes Portal. For more information, please visit the CP-724714 probe summary on the Chemical Probes Portal website.
This compound was developed by Pfizer for Kinase Phosphatase Biology research. To learn more about Sigma′s partnership with Pfizer and view other authentic, high-quality Pfizer compounds, visit sigma.com/bsm-pfizer.
 

法律信息

Sold for research purposes under agreement from Pfizer Inc.
Pfizer is a registered trademark of Pfizer, Inc.
 
 

属性

质量水平

100

测定

≥98% (HPLC)

形式

powder

mfr. no.

Pfizer®

颜色

white to beige

溶解性

DMSO: 20 mg/mL, clear

创始人

Pfizer

储存温度

room temp

SMILES string

COCC(NC/C=C/C1=CC=C(N=CN=C2NC3=CC=C(OC4=CC=C(C)N=C4)C(C)=C3)C2=C1)=O

InChI

1S/C27H27N5O3/c1-18-13-21(8-11-25(18)35-22-9-6-19(2)29-15-22)32-27-23-14-20(7-10-24(23)30-17-31-27)5-4-12-28-26(33)16-34-3/h4-11,13-15,17H,12,16H2,1-3H3,(H,28,33)(H,30,31,32)/b5-4+

InChI key

LLVZBTWPGQVVLW-SNAWJCMRSA-N

Gene Information

human ... ERBB2(2064)

 

安全信息

储存分类代码

13 - Non Combustible Solids

WGK

WGK 3

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储存温度 Storage temp.常温阴凉避光
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