CM琼脂糖凝胶FF [高流速]，CM Sepharose Fast Flow

图片 CM琼脂糖凝胶FF [高流速]，CM Sepharose Fast Flow
图片 CM琼脂糖凝胶FF [高流速]，CM Sepharose Fast Flow
图片 CM琼脂糖凝胶FF [高流速]，CM Sepharose Fast Flow
CM Sepharose Fast Flow是一种弱阳离子交换剂，基于完善的Sepharose Fast Flow离子交换平台，广泛用于研究和工业应用中的制备性蛋白质分离。订货号：17071910；17071905；17071901；17071960；17-0719-10；17-0719-05；17-0719-01；17-0719-60
制造商品牌: 思拓凡 Cytiva , (安)法玛西亚 Amersham Pharmacia
货号（SKU）: 17071901
CAS号: 68894-07-5
MDL号: MFCD00146478
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¥1,160.00

CM Sepharose Fast Flow

CM Sepharose Fast Flow is a weak cation exchanger based on the well established Sepharose Fast Flow ion exchange platform, extensively used for preparative protein separations in both research and industrial applications.

为工业下游工艺开发的经过充分验证的弱阳离子交换剂。
广泛用于各种批准的生物药物的捕获和中间纯化。
近几十年来离子交换色谱的行业标准。
高化学稳定性允许经过充分验证的 CIP 和消毒协议。
基础基质的亲水性确保非特异性结合水平较低，从而导致洗脱池中宿主细胞来源的杂质水平较低。
CM Sepharose Fast Flow 是 Sepharose Fast Flow 离子交换平台的一部分，该平台在近几十年来一直是离子交换色谱的工业标准。它由交联的 6% 琼脂糖颗粒组成，带有羧甲基 (CM) 弱阳离子交换基团。 CM Sepharose Fast Flow 具有高度的化学稳定性，可实现久经考验的原位清洗 (CIP) 和消毒方案。使用 CM Sepharose Fast Flow 进行放大是直接的，树脂可用于一系列预装工艺开发工具。

作为 BioProcess 树脂系列的一员，CM Sepharose Fast Flow 通过供应安全以及全面的技术和法规支持满足工业需求。

  • Well-proven weak cation exchanger developed for industrial downstream processes
  • Used extensively for capture and intermediate purification of a wide range of approved biopharmaceuticals
  • The industry standard for ion exchange chromatography during recent decades
  • High chemical stability allows for well proven CIP and sanitization protocols
  • The hydrophilic nature of the base matrix ensures low levels of non-specific binding leading to low levels of host cell-derived impurities in the elution pool.

CM Sepharose Fast Flow is part of the Sepharose Fast Flow ion exchange platform, which has been the industrial standard for ion exchange chromatography during recent decades. It is composed of cross-linked, 6% agarose particles, with carboxymethyl (CM) weak cation exchange groups. CM Sepharose Fast Flow has high chemical stability, allowing well proven cleaning-in-place (CIP) and sanitization protocols. Scale-up with CM Sepharose Fast Flow is straight forward and the resin is available in a range of pre-packed process development tools.

As member of the BioProcess resin range, CM Sepharose Fast Flow meets industrial demands with security of supply and comprehensive technical and regulatory support.

 

ParameterCM Sepharose Fast Flow
BioProcess resinYes 
LigandCarboxymethyl 
Particle size, d50V1~90 µm 
Ion Exchanger TypeWeak cation exchanger 
Matrixcross-linked agarose, 6%, spherical 
Particle Size45 μm-165 μm 
Ionic Capacity0.09-0.13 mmol H+/ml medium 
pH stability, operational24–13 
pH stability, CIP32–14 
pH ligand fully charged4Above 6 
Pressure/Flow Specification300-600 cm/h, 100 kPa, XK 50/30 column, bed height 15 cm 
Exclusion limit (Mr) (globular proteins)：~4 × 10⁶ 
Storage4 to 30°C, 20% Ethanol 
Chemical stability5Stable to commonly used aqueous buffers:1.0 M NaOH, 8 M urea, 8 M guanidine hydrochloride, 70% ethanol 
  • 1Median particle size of the cumulative volume distribution.
  • 2pH range where resin can be operated without significant change in function.
  • 3pH range where resin can be subjected to cleaning- or sanitization-in-place without significant change in function.
  • 4pH range where ligand is fully charged.
  • 51 M NaOH and acetic acid should be used only for cleaning purposes.
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储存温度 Storage temp.常温阴凉避光
全球实时库存 Availability √美国St. Louis ≥ 50 | 欧洲Eur. ≥ 12 | 東京Tokyo ≥ 20 | 香港与北京 ≥ 50
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