BX471,≥98% (HPLC)

别名:ZK-811752;(R)-1-(5-氯-2-(2-(4-(4-氟苄基)-2-甲基哌嗪-1-基)-2-氧代乙氧基)苯基)脲;N-[5-chloro-2-[2-[(2R)-4-[(4-fluorophenyl)methyl]-2-methyl-1-piperazinyl]-2-oxoethoxy]phenyl]-urea

Empirical Formula (Hill Notation): C21H24ClFN4O3 CAS号: 217645-70-0 分子量: 434.89 NACRES: NA.77
制造商品牌: 西格玛 Sigma-Aldrich
货号(SKU): SML0020
CAS号: 217645-70-0
MDL号: MFCD09859709
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¥2,014.79

说明

应用

BX471 has been used in chemotaxis assay to study the responses of HEK293 cells expressing human C-C motif chemokine receptor 1 (CCR1) to CC motif ligand 3 (CCL3)-induced cell migration.[1] It has also been used as a CCR1 inhibitor to assess the effects of CCR1 on the migration and epithelial-mesenchymal transition (EMT).[2]
 

生化/生理作用

BX471 blocks CCR1 and downregulates the mRNA expression of ICAM-1, P-selectin and E-selectin.[3] It decreases the inflammatory responses in sepsis,[3] prevents monocyte recruitment in inflammation sites in rheumatoid arthritis patients[4] and inhibits interstitial leukocyte recruitment and fibrosis in mouse model of lupus nephritis.[5]
BX471 is an orally active, CCR-1 specific antagonist. It displaces the endogenous CCR-1 ligands MIP-1a, RANTES and MCP-3 (Ki range 1-5 nM). BX471 inhibits CCR-1 effects in leukocytes, including calcium mobilization and migration.
 

特点和优势

This compound is featured on the Chemokine Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
This compound was developed by Bayer. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.
 
 

属性

质量水平

检测方案

≥98% (HPLC)

形式

powder

储存条件

desiccated

颜色

white to tan

溶解性

DMSO: ≥25 mg/mL

创始人

Bayer

储存温度

2-8°C

InChI

1S/C21H24ClFN4O3/c1-14-11-26(12-15-2-5-17(23)6-3-15)8-9-27(14)20(28)13-30-19-7-4-16(22)10-18(19)25-21(24)29/h2-7,10,14H,8-9,11-13H2,1H3,(H3,24,25,29)/t14-/m1/s1

InChI key

XQYASZNUFDVMFH-CQSZACIVSA-N

 

安全信息

储存分类代码

11 - Combustible Solids

WGK

WGK 3

商品规格
属性名称属性值
储存温度 Storage temp.2-8°C冷藏
全球实时库存 Availability √美国St. Louis ≥ 10 | 欧洲Eur. ≥ 8 | 東京Tokyo ≥ 6 | 香港与北京 ≥ 60