Application
一种选择性的组蛋白甲基转移酶（HMTASE）抑制剂。
BIX01294 hydrochloride inhibits G9a. The histone methyltransferase (HMTase) G9a can mono- or dimethylate lysine 9 on histone 3 (H3), contributing to early embryogenesis, genomic imprinting, and lymphocyte development. BIX01294 hydrochloride is a selective inhibitor of G9a HMTase (IC50 = 1.7 μM). It less effectively inhibits the HMTase G9a-like protein (GLP; IC50 = 38 μM) and has no effect on other known HMTases. BIX01294 hydrochloride has been used in combination with the calcium channel activator BayK8644 to facilitate the generation of induced pluripotent stem cells from somatic cells in vitro. BIX01294 hydrochloride is an inhibitor of HDAC.
BIX01294盐酸盐抑制G9a。 组蛋白甲基转移酶（HMTase）G9a可以对组蛋白3（H3）上的赖氨酸9单或二甲基化，有助于早期胚胎发生，基因组印迹和淋巴细胞发育。 盐酸盐BIX01294是G9a HMTase的选择性抑制剂（IC50 = 1.7μM）。 它不太有效地抑制HMTase G9a样蛋白（GLP； IC50 = 38μM），对其他已知的HMTase没有影响。 BIX01294盐酸盐已与钙通道激活剂BayK8644结合使用，以促进体外从体细胞产生诱导性多能干细胞。 BIX01294盐酸盐是HDAC的抑制剂。
Properties
| Iupac Name | N-(1-benzyl-4-piperidinyl)-6,7-dimethoxy-2-(4-methyl-1,4-diazepan-1-yl)-4-quinazolinamine trihydrochloride hydrate |
| Inchi Code | 1S/C28H38N6O2.3ClH.H2O/c1-32-12-7-13-34(17-16-32)28-30-24-19-26(36-3)25(35-2)18-23(24)27(31-28)29-22-10-14-33(15-11-22)20-21-8-5-4-6-9-21;;;;/h4-6,8-9,18-19,22H,7,10-17,20H2,1-3H3,(H,29,30,31);3*1H;1H2 |
| Inchi Key | BZOWJAYUMMHCDW-UHFFFAOYSA-N |
安全信息
RIDADR NONH for all modes of transport
