BAM8-22三氟乙酸盐，BAM8-22 trifluoroacetate salt；≥98% (HPLC)

图片 BAM8-22三氟乙酸盐，BAM8-22 trifluoroacetate salt；≥98% (HPLC)
别名：BAM (8-22) trifluoroacetate salt, Bovine Adrenal Medulla 8-22 trifluoroacetate salt, Bovine adrenal medulla peptide (8-22) trifluoroacetate salt, L-Valyl-glycyl-L-arginyl-L-prolyl-L-α-glutamyl-L-tryptophyl-L-tryptophyl-L-methionyl-L-α-aspartyl-L-tyrosyl-L-glutaminyl-L-lysyl-L-arginyl-L-tyrosyl-glycine trifluoroacetate salt, VGRPEWWMDYQKRYG trifluoroacetate salt, Val-Gly-Arg-Pro-Glu-Trp-Trp-Met-Asp-Tyr-Gln-Lys-Arg-Tyr-Gly trifluoroacetate salt

经验公式（希尔记法）: C91H127N25O23S · xC2HF3O2 CAS号: 412961-36-5 分子量: 1971.20 (free base basis) NACRES: NA.77
制造商品牌: 西格玛 Sigma-Aldrich
货号（SKU）: SML0729
CAS号: 412961-36-5
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说明

Amino Acid Sequence

Val-Gly-Arg-Pro-Glu-Trp-Trp-Met-Asp-Tyr-Gln-Lys-Arg-Tyr-Gly trifluoroacetate salt
 

应用

BAM8-22 trifluoroacetate salt has been used in the study to identify the functions of Mas-related gene (Mrg) C in the pathogenesis and treatment of bone cancer pain (BCP).[1]
 

生化/生理作用

BAM8-22 is a selective agonist for the sensory neuron specific G-protein coupled receptors (SNSRs). BAM8-22 inhibits development of morphine tolerance in rats. BAM8-22 is inactive at opioid receptors. Also, BAM8–22 is a potent activator of Mas-related G-protein-coupled receptors (Mrgprs), MrgprC11 and hMrgprX1. BAM8-22 produces itch and nociceptive sensations in humans in a histamine-independent manner.
Bovine adrenal medulla 8-22 (BAM8-22), a 15-amino acid peptide, acts a cleavage product of proenkephalin A and the precursor of Leu- and Met-enkephalin in the adrenal medulla. It may also be used to treat pain. It blocks inflammatory pain, chemical pain and downregulates the expression of spinal c-fos gene in an opioid-independent manner. In mice, BAM8-22 diminishes bone cancer pain. It induces the expression of Mas-related G-protein-coupled receptor C (MrgC) in the spinal dorsal horn.[2]
 
 

属性

质量水平

100

检测方案

≥98% (HPLC)

形式

powder

颜色

white to off-white

运输

wet ice

储存温度

−20°C

InChI

1S/C91H127N25O23S/c1-48(2)76(94)88(138)103-46-72(120)105-64(19-11-36-100-91(97)98)89(139)116-37-12-20-70(116)87(137)110-62(30-32-73(121)122)81(131)113-68(42-52-45-102-58-16-7-5-14-56(52)58)85(135)114-67(41-51-44-101-57-15-6-4-13-55(51)57)84(134)109-63(33-38-140-3)82(132)115-69(43-74(123)124)86(136)112-66(40-50-23-27-54(118)28-24-50)83(133)108-61(29-31-71(93)119)80(130)106-59(17-8-9-34-92)78(128)107-60(18-10-35-99-90(95)96)79(129)111-65(77(127)104-47-75(125)126)39-49-21-25-53(117)26-22-49/h4-7,13-16,21-28,44-45,48,59-70,76,101-102,117-118H,8-12,17-20,29-43,46-47,92,94H2,1-3H3,(H2,93,119)(H,103,138)(H,104,127)(H,105,120)(H,106,130)(H,107,128)(H,108,133)(H,109,134)(H,110,137)(H,111,129)(H,112,136)(H,113,131)(H,114,135)(H,115,132)(H,121,122)(H,123,124)(H,125,126)(H4,95,96,99)(H4,97,98,100)/t59-,60-,61-,62-,63-,64-,65-,66-,67-,68-,69-,70-,76-/m0/s1

InChI key

GOEYECACIBFJGZ-NPAGUKBMSA-N

 

安全信息

储存分类代码

11 - Combustible Solids

WGK

WGK 3

商品规格
属性名称属性值
储存温度 Storage temp.-20°C低温冷冻
全球实时库存 Availability √美国St. Louis ≥ 50 | 欧洲Eur. ≥ 12 | 東京Tokyo ≥ 20 | 香港与北京 ≥ 50
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