AG126,≥99% (HPLC)

别名:AG-126;AG 126;2-(3-羟基-4-硝基苯亚甲基)丙二腈;α-Cyano-(3-hydroxy-4-nitro)cinnamonitrile

Empirical Formula (Hill Notation): C10H5N3O3 CAS号: 118409-62-4 分子量: 215.17
货号(SKU): A06149
CAS号: 118409-62-4
MDL号: MFCD00236448
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¥2,272.41

说明

一般描述

A cell-permeable inhibitor of lipopolysaccaride (LPS)-induced synthesis of tumor necrosis factor-α and nitric oxide in murine peritoneal macrophages. Blocks LPS-induced tyrosine phosphorylation of a p42MAPK protein substrate.
A cell-permeable inhibitor of lipopolysaccharide (LPS)-induced synthesis of tumor necrosis factor-α and nitric oxide in murine peritoneal macrophages. Blocks LPS-induced tyrosine phosphorylation of a p42MAPK/ERK2 protein substrate. Reduces the expression of iNOS and COX-2 in lungs of rats treated with carrageenan. Blocks glucocorticoid-induced COX-2 activity in human amnion cells (IC50 = 15.38 µM).
 

生化/生理作用

Cell permeable: yes
Primary Target
COX-2 activity
Product does not compete with ATP.
Reversible: no
Target IC50: 15.38 µM in blocking glucocorticoid-induced COX-2 activity in human amnion cells
 

警告

Toxicity: Toxic (F)
 

其他说明

Cuzzocrea, S., et al. 2000. Am. J. Pathol.157, 145.
Zakar, T., et al. 1999. Can. J. Physiol. Pharmacol.77, 138.
Kan, H., et al. 1996. Mol. Pharmacol.50, 1139.
Novogrodsky, A., et al. 1994. Science264, 1319.
Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
 

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
 
 

属性

质量水平

检测方案

≥95% (HPLC)

形式

solid

manufacturer/tradename

Calbiochem®

储存条件

OK to freeze
protect from light

颜色

yellow

溶解性

DMSO: 5 mg/mL
DMF: soluble

运输

ambient

储存温度

−20°C

InChI

1S/C10H5N3O3/c11-5-8(6-12)3-7-1-2-9(13(15)16)10(14)4-7/h1-4,14H

InChI key

DUQADSPERJRQBW-UHFFFAOYSA-N

 

安全信息

储存分类代码

11 - Combustible Solids

WGK

WGK 3

商品规格
属性名称属性值
储存温度 Storage temp.-20°C低温冷冻
全球实时库存 Availability √美国St. Louis ≥ 30 | 欧洲Eur. ≥ 10 | 東京Tokyo ≥ 9 | 香港与北京 ≥ 30