2-溴-1-乙基吡啶四氟硼酸盐，2-Bromo-1-ethyl-pyridinium tetrafluoroborate [BEP]；≥97.0% (T)

2-Bromo-1-ethyl-pyridinium tetrafluoroborate is a coupling reagent employed in the synthesis of amides and esters through amidation and esterification reactions, respectively. It is generally prepared by the reaction of triethyloxonium tetrafluoroborate with 2?bromo pyridine.[1]

 

2-Bromo-1-ethyl-pyridinium tetrafluoroborate can be used as a coupling reagent for:

• The synthesis of N-methylated peptides in solution and solid phase.[2]
• The synthesis of cyclosporin A fragment and dolastatin 15 pentapeptide moiety.[3]

用于肽合成的偶联试剂；与其他试剂如 BOP、PyBrOP、PyClU、BTFFH、CMBI 相比，外消旋作用更低、反应更快[4]