黄峰毒素，Mastoparan, Vespula lewisii；≥97% (HPLC), powder

图片 黄峰毒素，Mastoparan, Vespula lewisii；≥97% (HPLC), powder
G蛋白激活剂；经验公式（希尔记法）: C70H131N19O15 CAS号: 72093-21-1 分子量: 1478.91 Beilstein: 5491949 MDL编号: MFCD00076865 PubChem化学物质编号: 329818006 NACRES: NA.32
制造商品牌: 西格玛 Sigma-Aldrich
货号（SKU）: M5280
CAS号: 72093-21-1
MDL号: MFCD00076865
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说明

Amino Acid Sequence

Ile-Asn-Leu-Lys-Ala-Leu-Ala-Ala-Leu-Ala-Lys-Lys-Ile-Leu-NH2
 

一般描述

Mastoparan is a cationic, amphiphilic, tetradecapeptide amide. It is composed of the restricted amino acid and the repeated sequence.[1] This protein is a nonspecific secretagogue isolated from venom of wasp.[2]
 

应用

Mastoparan has been used as a calmodulin antagonist.[3]
 

生化/生理作用

Mast cell degranulating peptide. Activates phospholipase A2; inhibits calmodulin. Cell permeable; stimulates exocytosis and phosphoinositide breakdown.
Mastoparan effectively stimulates exocytosis from diverse mammalian cells. The encoded protein facilitates the secretion of histamine from mast cells, serotonin from platelets, catecholamines from chromaffin cells and prolactin from the anterior pituitary.[2] In addition, it is also involved in activation of Phospholipase A2 and phosphoinositides (Pl) break down. Mastoparan functions as an inhibitor for calmodulin-stimulated phosphodiesterase.[4][5][6] Mastoparan helps in mitochondrial permeability transition by enhancing an apparent bimodal mechanism of action.[7]
 

其他说明

Lyophilized from 0.1% TFA in H2O
 
 

属性

生物来源

synthetic

质量水平

200

检测方案

≥97% (HPLC)

形式

powder

颜色

white

储存温度

−20°C

SMILES字符串

CC[C@H](C)[C@H](N)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)NC([C@@H](C)CC)C(=O)N[C@@H](CC(C)C)C(N)=O

InChI

1S/C70H131N19O15/c1-17-40(11)55(75)69(103)88-53(35-54(74)90)68(102)87-52(34-39(9)10)67(101)83-46(25-19-22-28-71)62(96)78-45(16)61(95)86-50(32-37(5)6)65(99)79-42(13)58(92)77-43(14)60(94)85-51(33-38(7)8)66(100)80-44(15)59(93)81-47(26-20-23-29-72)63(97)82-48(27-21-24-30-73)64(98)89-56(41(12)18-2)70(104)84-49(57(76)91)31-36(3)4/h36-53,55-56H,17-35,71-73,75H2,1-16H3,(H2,74,90)(H2,76,91)(H,77,92)(H,78,96)(H,79,99)(H,80,100)(H,81,93)(H,82,97)(H,83,101)(H,84,104)(H,85,94)(H,86,95)(H,87,102)(H,88,103)(H,89,98)/t40-,41-,42-,43-,44-,45-,46-,47-,48-,49-,50-,51-,52-,53-,55-,56-/m0/s1

InChI key

MASXKPLGZRMBJF-MVSGICTGSA-N

基因信息

human ... CALM1(801) , PLA2R1(22925)
mouse ... CALM1(12313) , PLA2R1(18779)
rat ... CALM1(24242) , PLA2R1(295631)

 

安全信息

储存分类代码

11 - Combustible Solids

WGK

WGK 3

个人防护装备

Eyeshields, Gloves, type N95 (US)

商品规格
属性名称属性值
储存温度 Storage temp.-20°C低温冷冻
全球实时库存 Availability √美国St. Louis ≥ 50 | 欧洲Eur. ≥ 12 | 東京Tokyo ≥ 20 | 香港与北京 ≥ 50
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