鲁斯可皂苷元，Ruscogenin；≥98% (HPLC)

图片 鲁斯可皂苷元，Ruscogenin；≥98% (HPLC)
别名：(1β,3β,25R)-5-烯-1,3-二醇；(1β,3β,25R)-Spirost-5-ene-1,3-diol；Empirical Formula (Hill Notation): C27H42O4 CAS号: 472-11-7 分子量: 430.62 MDL编号: MFCD00210550 PubChem化学物质编号: 329824928 NACRES: NA.25
制造商品牌: 西格玛 Sigma-Aldrich
货号（SKU）: SMB00295
CAS号: 472-11-7
MDL号: MFCD00210550
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说明

一般描述

Ruscogenin is a major steroidal saponin found in the root of Ophiopogon japonicus. It was first isolated from Ruscus aculeatus.
 

应用

Ruscogenin has been used to study its therapeutic effects on Crohn′s disease (CD)-like colitis both in vitro and in vivo studies.
 

生化/生理作用

Ruscogenin is a well-known compound for down-regulating nuclear factor kappa B (NF-κB), intercellular adhesion molecule-1 (ICAM-1), tissue factor (TF), inducible NO synthase (iNOS), and modulating inflammatory pathways. It displays anti-inflammatory properties by inhibiting lipopolysaccharide (LPS)-induced acute lung injury (ALI), and improving diabetic nephropathy in in vivo studies. Ruscogenin also exerts neuroprotective properties and protects the brain against ischemic injury in mouse model. It elicits anti-tumor properties by inducing ferroptosis in pancreatic cancer cells in both in vitro and in vivo studies.
 
 

属性

质量水平

200

检测方案

≥98% (HPLC)

形式

powder

储存温度

−20°C

SMILES string

C[C@H](CC1)CO[C@]21O[C@@]3([H])C[C@@]4([H])[C@]5([H])CC=C6C[C@@H](O)C[C@@H](O)[C@]6(C)[C@@]5([H])CC[C@]4(C)[C@@]3([H])[C@@H]2C

InChI

1S/C27H42O4/c1-15-7-10-27(30-14-15)16(2)24-22(31-27)13-21-19-6-5-17-11-18(28)12-23(29)26(17,4)20(19)8-9-25(21,24)3/h5,15-16,18-24,28-29H,6-14H2,1-4H3/t15-,16+,18-,19-,20+,21+,22+,23-,24+,25+,26+,27-/m1/s1

InChI key

QMQIQBOGXYYATH-IDABPMKMSA-N

 

安全信息

储存分类代码

11 - Combustible Solids

WGK

WGK 3

商品规格
属性名称属性值
储存温度 Storage temp.-20°C低温冷冻
全球实时库存 Availability √美国St. Louis ≥ 20 | 欧洲Eur. ≥ 16 | 東京Tokyo ≥ 5 | 香港与北京 ≥ 20
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