马兜铃酸I，Aristolochic acid I；powder

Aristolochic acid is a naturally occurring plant metabolite found in Aristolochia sp, Bragantia sp. or Asarum sp. plants.[1] It comprises a mixture of nitrophenanthrene carboxylic acids such as aristolochic acid I and II.[2]

 

马兜铃酸I是一种有效的磷脂酶A₂ 抑制剂。 马兜铃酸I可诱导大鼠肾脏中的肿瘤形成和人肾脏近端小管上皮细胞的凋亡。

Aristolochic acid I have been used:

• as a standard for the analysis of Aristolochia sprucei crude extract by high-performance liquid chromatography[3]
• to study its effects on histone deacetylase 3 (HDAC3) aberration and renal fibrosis[4]
• to induce acute aristolochic acid nephropathy and to study its impact on miRNA and mRNA expression in mice[5]

Aristolochic acid is a potent inhibitor of phospholipase A2 (PLA2), hyaluronidase, and acetylcholinesterase plasma proteases from snake venoms.[6] Aristolochic acid is considered a herbal medicine and shows therapeutic effects against obstetrics, snake bites, gout, and rheumatism.[2] It exhibits anti-inflammatory and anti-malarial properties.[7] In addition, it is also considered a genotoxic mutagen[2] and causes aristolochic acid nephropathy (AAN), characterized by interstitial fibrosis and urothelial cancer.[2]

有效的磷脂酶A₂ 抑制剂，包括钙离子载体诱导的嗜中性粒细胞磷脂酶A₂ 活性。实验动物模型的肾肿瘤引发剂。