达卡巴嗪，Dacarbazine [DTIC]；antineoplastic purine analog

图片 达卡巴嗪，Dacarbazine [DTIC]；antineoplastic purine analog
有抗黑色素瘤活性，抗肿瘤嘌呤类似物；别名：5-（3,3-二甲基-1-三氮烯基）咪唑-4-羧酰胺；5-(3,3-Dimethyl-1-triazenyl)imidazole-4-carboxamide, DTIC

Empirical Formula (Hill Notation): C6H10N6O CAS号: 4342-03-4 分子量: 182.18 EC 号: 224-396-1 MDL编号: MFCD00057167 PubChem化学物质编号: 24893683 NACRES: NA.85
制造商品牌: 西格玛 Sigma-Aldrich
货号（SKU）: D2390
CAS号: 4342-03-4
MDL号: MFCD00057167
签订合同 √ 正规发票 √ 技术支持 √ 质量保障 √ 全程可追溯 √
¥656.20

说明

应用

Dacarbazine is a triazine antineoplastic agent that is used for DNA methylation via formation of methyl adducts. It is used to treat metastatic malignant melanomas and Hodgkin′s when used in combination with other antineoplastic agents.
 

生化/生理作用

Dacarbazine is a purine analog of naturally occurring purine precursor 5-amino-1H-imidazole-4-carboxamide (AIC). It is a synthetic triazine antineoplastic agent that exerts cytotoxic effects by acting as an alkylating agent and by inhibiting DNA synthesis and inducing apoptosis.[1] It is known to induce hepatotoxicity in mice.[2] Dacarbazine is not cell cycle-phase specific.
 

其他说明

Keep container tightly closed in a dry and well-ventilated place.
 
 

属性

质量水平

100

形式

powder or crystals

溶解性

1 M HCl: 50 mg/mL

抗生素抗菌谱

neoplastics

作用机制

DNA synthesis | interferes

储存温度

2-8°C

SMILES string

CN(C)\N=N\c1[nH]cnc1C(N)=O

InChI

1S/C6H10N6O/c1-12(2)11-10-6-4(5(7)13)8-3-9-6/h3H,1-2H3,(H2,7,13)(H,8,9)/b11-10+

InChI key

FDKXTQMXEQVLRF-ZHACJKMWSA-N

 

安全信息

象形图

Exclamation markHealth hazard
GHS07,GHS08

警示用语：

Danger

危险分类

Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Carc. 1B - Eye Irrit. 2 - Muta. 1B - Skin Irrit. 2 - STOT SE 3

靶器官

Respiratory system

储存分类代码

6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

个人防护装备

Eyeshields, Gloves, type P3 (EN 143) respirator cartridges

商品规格
属性名称属性值
储存温度 Storage temp.2-8°C冷藏
全球实时库存 Availability √美国St. Louis ≥ 20 | 欧洲Eur. ≥ 16 | 東京Tokyo ≥ 5 | 香港与北京 ≥ 20
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