藤黄酸，Gambogic acid；≥95% (TLC)

图片 藤黄酸，Gambogic acid；≥95% (TLC)
别名：β-藤黄酸；藤黄酸；1,5-甲醇-1H,3H,11H-呋喃(3,4-g)吡喃(3,2-b)氧杂蒽-1-巴豆酸；B"-Guttiferrin, 1,5-Methano-1H,3H,11H-furo(3,4-g)pyrano(3,2-b)xanthene-1-crotonic acid, Cambogic acid, Guttic acid, Beta-Guttilactone, Beta-Guttiferrin, Guttatic acid

Empirical Formula (Hill Notation): C38H44O8 CAS号: 2752-65-0 分子量: 628.75
制造商品牌: 色谱科 Supelco , 西格玛 Sigma-Aldrich
货号（SKU）: 345701
CAS号: 2752-65-0
MDL号: MFCD16878985
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¥2,947.72

说明

A cell-permeable caspase activator and an apoptosis inducer that was originally isolated from gamboge resin for its antimicrobial properties.

一种可渗透细胞的半胱天冬酶激活剂和细胞凋亡诱导剂，最初是从藤黄树脂中分离出来的，因为它具有抗菌特性。

一般描述

A cell-permeable, anti-microbial xanthone orignally isolated from the gamboge resin of Garcinia hanburyi. Acts as a caspase activator and apoptosis inducer. Shown to inhibit the growth of HeLa and HEL cells (MIC = 12.5 µg/ml). Reported to block telomerase activity in SMMC-7721 cells. Shown to induce tyrosine kinase phosphatase SHP-1 and suppress Stat3 activation.
A cell-permeable caspase activator and an apoptosis inducer that was originally isolated from gamboge resin for its antimicrobial properties. Shown to inhibit the growth of HeLa and HEL cells minimal inhibitory concentrations (MIC = 12.5 µg/ml).
 

生化/生理作用

Cell permeable: yes
Primary Target
Caspase activator and an apoptosis inducer
MIC = 12.5 µg/ml in inhibiting the growth of HeLa and HEL cells
Product does not compete with ATP.
Reversible: no
 

警告

Toxicity: Toxic & Carcinogenic / Teratogenic (G)
 

其他说明

Prasad, S., et al. 2011. Cancer Prev. Res.4, 1084.
Guo, Q.L., et al. 2004. Acta Pharmacol. Sin.25, 769.
Asano, J., et al. 1996. Phytochemistry41, 815.
Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
 

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
 
 

属性

质量水平

100

测定

≥95% (TLC)

形式

amorphous solid

manufacturer/tradename

Calbiochem®

储存条件

OK to freeze
protect from light

颜色

orange

溶解性

DMSO: 10 mg/mL
ethanol: soluble

运输

ambient

储存温度

2-8°C

InChI

1S/C38H44O8/c1-20(2)10-9-15-36(8)16-14-24-29(39)28-30(40)26-18-23-19-27-35(6,7)46-37(33(23)41,17-13-22(5)34(42)43)38(26,27)45-32(28)25(31(24)44-36)12-11-21(3)4/h10-11,13-14,16,18,23,27,39H,9,12,15,17,19H2,1-8H3,(H,42,43)/b22-13-/t23?,27?,36-,37?,38-/m1/s1

InChI key

GEZHEQNLKAOMCA-PLUQQRNKSA-N

 

安全信息

象形图

Skull and crossbones
GHS06

警示用语：

Danger

危险分类

Acute Tox. 3 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

靶器官

Respiratory system

储存分类代码

6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 1

商品规格
属性名称属性值
储存温度 Storage temp.2-8°C冷藏
全球实时库存 Availability √美国St. Louis ≥ 10 | 欧洲Eur. ≥ 8 | 東京Tokyo ≥ 6 | 香港与北京 ≥ 60
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