左旋溶肉瘤素 [米尔法兰]，Melphalan [L-PAM]；≥95%, HPLC

图片 左旋溶肉瘤素 [米尔法兰]，Melphalan [L-PAM]；≥95%, HPLC
别名：美法仑；左旋苯丙氨酸氮芥；米尔法兰；马法兰；马尔法兰；左旋溶肉瘤素；4-[Bis(2-chloroethyl)amino]-L-phenylalanine, L-PAM, L-Phenylalanine mustard

Empirical Formula (Hill Notation): C13H18Cl2N2O2 CAS号: 148-82-3 分子量: 305.20 Beilstein: 2816456 EC 号: 205-726-3 MDL编号: MFCD00057717 PubChem化学物质编号: 24278538 NACRES: NA.32
制造商品牌: 西格玛 Sigma-Aldrich
货号（SKU）: M2011
CAS号: 148-82-3
MDL号: MFCD00057717
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¥2,323.30

说明

一般描述

Melphalan also known as L-phenylalanine mustard is an alkylating agent.[1][2] It belongs to the class of nitrogen mustards, which act as chemotherapeutic agents.[1]
 

应用

Melphalan has been used as a drug along with HDAC-inhibitor JNJ-26481585 to treat multiple myeloma (MM) in cell lines and as a chemotherapeutic agent for breast cancer cell line.[3][4]
 

生化/生理作用

In rat, melphalan in isolated lung perfusion (ILP) functions as a potent therapeutics for sarcomatous pulmonary metastases. It forms DNA intrastrand crosslinks by bifunctional alkylation in 5′-GGC sequences.[1] Melphalan acts as a bone-marrow depressant and is implicated in the treatment of multiple myeloma and ovarian cancer.[2][5]
Melphalan is an antineoplastic agent.[6][7]
 
 

属性

形式

powder

质量水平

200

颜色

white

SMILES string

N[C@@H](Cc1ccc(cc1)N(CCCl)CCCl)C(O)=O

InChI

1S/C13H18Cl2N2O2/c14-5-7-17(8-6-15)11-3-1-10(2-4-11)9-12(16)13(18)19/h1-4,12H,5-9,16H2,(H,18,19)/t12-/m0/s1

InChI key

SGDBTWWWUNNDEQ-LBPRGKRZSA-N

 

安全信息

象形图

Skull and crossbonesHealth hazard
GHS06,GHS08

警示用语：

Danger

危险分类

Acute Tox. 2 Oral - Carc. 1A - Muta. 1B - Repr. 2 - Skin Sens. 1

储存分类代码

6.1B - Non-combustible, acute toxic Cat. 1 and 2 / very toxic hazardous materials

WGK

WGK 3

个人防护装备

Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges

商品规格
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储存温度 Storage temp.常温阴凉避光
全球实时库存 Availability √美国St. Louis ≥ 20 | 欧洲Eur. ≥ 16 | 東京Tokyo ≥ 5 | 香港与北京 ≥ 20
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