积雪草酸 [亚细亚酸]，Asiatic acid [AA]；≥98% (HPLC), from Centella asiatica

别名：2α, 23-二羟基熊果酸；达玛醇酸；2α,23-Dihydroxyursolic acid, Dammarolic acid, NSC 166063

Empirical Formula (Hill Notation): C30H48O5 CAS号: 464-92-6 分子量: 488.70 EC 号: 482-720-9

制造商品牌: 西格玛 Sigma-Aldrich

货号（SKU）: A2612

CAS号: 464-92-6

MDL号: MFCD00238541

签订合同 √ 正规发票 √ 技术支持 √ 质量保障 √ 全程可追溯 √

目录价.SKU-Variant

10mg
50mg [+¥5,712.83]
200mg [+¥10,400.69]
1g [+¥16,501.15]

¥3,099.57

数量:

说明

积雪草酸是一种天然存在的五环三萜类化合物，从积雪草中获得。积雪草酸已用于体外研究其在胶质母细胞瘤细胞中的细胞毒性潜力。它还被用于积雪草中积雪草酸的体内定量分析和使用有机诱导剂提高积雪草酸产量的体外研究。

据报道，积雪草酸对胶质母细胞瘤、乳腺癌、肝癌、黑色素瘤和结肠癌具有有害作用，并具有抗血管生成活性。此外，它可以穿过血脑屏障，引起人恶性胶质瘤和肝癌细胞的凋亡。积雪草酸还有效抑制紫外线 A 调制的信号转导途径，因此可用于对抗 UVA 引起的皮肤光老化。已经注意到它显示出抗伤害和抗炎特性以及对 β-淀粉样蛋白和谷氨酸诱导的神经毒性的抑制作用。

一般描述

Asiatic acid is a naturally occurring pentacyclic triterpenoid, obtained from Centella asiatica.

应用

积雪草酸衍生物合成的起始物料：

抗癌药
糖原磷酸化酶抑制剂
肝保护剂

Asiatic acid has been used in the in vitro study of its cytotoxic potential in glioblastoma cells. It has also been used for the in vivo quantitative analysis of asiatic acid in Centella asiatica L. and in vitro study of enhancement of asiatic acid yield upon using organic elicitors.

生化/生理作用

Asiatic acid has been reported to exhibit a pernicious effect on glioblastoma, breast, liver, melanoma, and colon cancers and anti-angiogenic activity. Additionally, it can cross the blood-brain barrier and cause apoptosis in human malignant glioma and hepatoma cells. Asiatic acid also effectively inhibits the Ultraviolet A modulated signal transduction pathways and thereby can be used against UVA-induced photoaging of the skin. It has been noted to show antinociceptive and anti-inflammatory properties plus inhibitory effect on neurotoxicity induced by β-amyloid and glutamate.

积雪草酸常用于伤口愈合。积雪草酸具有抗氧化、抗炎和神经保护属性

属性

质量水平

200

生物来源

Centella asiatica

测定

≥98% (HPLC)

形式

powder

储存条件

protect from light

颜色

white

mp

325-330 °C (lit.)

溶解性

methanol: 1 mg/mL, clear, colorless

储存温度

2-8°C

SMILES string

C[C@@H]1CC[C@@]2(CC[C@]3(C)C(=CC[C@@H]4[C@@]5(C)C[C@@H](O)[C@H](O)[C@@](C)(CO)[C@@H]5CC[C@@]34C)[C@@H]2[C@H]1C)C(O)=O

InChI

1S/C30H48O5/c1-17-9-12-30(25(34)35)14-13-28(5)19(23(30)18(17)2)7-8-22-26(3)15-20(32)24(33)27(4,16-31)21(26)10-11-29(22,28)6/h7,17-18,20-24,31-33H,8-16H2,1-6H3,(H,34,35)/t17-,18+,20-,21-,22-,23+,24+,26+,27+,28-,29-,30+/m1/s1

InChI key

JXSVIVRDWWRQRT-UYDOISQJSA-N

安全信息

储存分类代码

11 - Combustible Solids

WGK

WGK 3

商品规格

属性名称	属性值
储存温度 Storage temp.	2-8°C冷藏
全球实时库存 Availability √	美国St. Louis ≥ 20 \| 欧洲Eur. ≥ 16 \| 東京Tokyo ≥ 5 \| 香港与北京 ≥ 20

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