福司曲星钠盐 [卵泡抑素]，Fostriecin sodium salt from Streptomyces pulveraceus [FST]；≥98% (HPLC)

Fostriecin has been used as a protein phosphatases type 2A (PP2A) inhibitor to study its effects on phosphorylated myosin light chain (pMLC) levels in axon initial segments (AIS).[1] It has also been used as a PP2A inhibitor to study its effects on the regulation of protein kinase Akt (pAKT) by dopamine (DA) in larval zebrafish brain.[2]

 

Fostriecin is a natural inhibitor of serine/ threonine phosphatases.[3] It is a phosphate monoester produced by fermentation beer of Streptomyces pulveraceus.[3][4] Fostriecin is a strong inhibitor of protein phosphatases type 2A and 4 (PP2A and PP4) and a weak inhibitor of protein phosphatases type 1 and 5 (PP1 and PP5).[3] It exhibits anti-tumor activity against several tumor cells in vitro and L1210 and P388 leukemias in vivo.[4] The anti-tumor activity of fostriecin is due to its ability to interfere with the reversible phosphorylation of proteins that are involved in the progression of the cell cycle.[4] It also exhibits cytotoxic effects.[3] Fostriecin can inhibit the DNA, RNA and protein synthesis.[4]

 

This compound is featured on the Phosphoprotein Phosphatases (Serine/Threonine) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.