茶碱，Theophylline；analytical standard, ≥99.0%, HPLC

图片 茶碱，Theophylline；analytical standard, ≥99.0%, HPLC
别名：氨茶碱标准品；无水氨茶碱；1,3-二甲基黄嘌呤；2,6-二羟基-1,3-二甲基嘌呤；3,7-二氢-1,3-二甲基-1H-嘌呤-2,6-二酮；1,3-Dimethylxanthine, 2,6-Dihydroxy-1,3-dimethylpurine, 3,7-Dihydro-1,3-dimethyl-1H-purine-2,6-dione

CAS号 58-55-9 经验分子式（希尔表示法） C7H8N4O2 分子量 180.16 Beilstein/REAXYS Number 13463 EINECS 编号 200-385-7 MDL number MFCD00079619 PubChem Substance ID 24277677 NACRES NA.77
制造商品牌: BSZH
货号（SKU）: T0385
CAS号: 58-55-9
MDL号: MFCD00079619
签订合同 √ 正规发票 √ 技术支持 √ 质量保障 √ 全程可追溯 √
¥1,260.00

产品描述

一种竞争性非选择性磷酸二酯酶抑制剂；

茶碱是一种茶生物碱，起非选择性PDE4抑制剂的作用。 它可以在哮喘患者的支气管中引起平滑肌松弛。 在增加的浓度下，茶碱可以起生殖毒性剂的作用，并通过使支持细胞失去功能而引起不育。 随后，这会导致后期分化的生精细胞过早释放。磷酸二酯酶抑制剂； 利尿剂 心脏兴奋剂 肌肉松弛剂 哮喘药物。

Application

Theophylline has been used to study its effects on rat gene expression in the ubiquitin-proteasome pathway that regulates spermatogenesis and epididymal sperm quality. Theophylline has also been used as an internal standard for the measurement of plasma paracetamol levels in humans.

Biochem/physiol Actions

Theophylline is a tea alkaloid that functions as a nonselective PDE4 inhibitor. It can induce smooth muscle relaxation in the bronchiolae of asthma patients. At increased concentrations, theophylline can function as a reprotoxic agent and can cause infertility by incapacitating Sertoli cells. This subsequently causes the premature release of late differentiating spermatogenic cells[2].

Phosphodiesterase inhibitor; diuretic; cardiac stimulant; muscle relaxant; asthma medication.

性质

grade  anhydrous
assay  ≥99%
form  powder
color  white
solubility  H2O: slightly soluble 8.3 mg/ml
 NH4OH: 50 mg/ml, clear, colorless
 alcohol: 12.5 mg/ml
 chloroform: soluble 9.1 mg/ml
 0.1 M HCl: soluble
 0.1 M NaOH: soluble
 ammonium hydroxide: soluble
 aqueous base: soluble
 diethyl ether: slightly soluble
 dilute HCl: soluble
 dilute nitric acid: soluble
 ethanol: moderately soluble
originator  Forest Labs
SMILES string：  CN1C(=O)N(C)c2[nH]cnc2C1=O
InChI  1S/C7H8N4O2/c1-10-5-4(8-3-9-5)6(12)11(2)7(10)13/h3H,1-2H3,(H,8,9)
InChI key  ZFXYFBGIUFBOJW-UHFFFAOYSA-N


安全信息

符号
GHS06  GHS06
信号词 Danger
危害声明 H301
个人防护装备 dust mask type N95 (US), Eyeshields, Faceshields, Gloves
危害码 (欧洲) Xn
风险声明 (欧洲) 22
RIDADR UN 2811 6.1 / PGIII
WGK德国 WGK 1
RTECS XH3850000
商品规格
属性名称属性值
储存温度 Storage temp.常温阴凉避光
全球实时库存 Availability √美国St. Louis ≥ 50 | 欧洲Eur. ≥ 12 | 東京Tokyo ≥ 20 | 香港与北京 ≥ 50
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