普马司他盐酸盐，Prinomastat hydrochloride；≥95% (HPLC)

图片 普马司他盐酸盐，Prinomastat hydrochloride；≥95% (HPLC)
别名：盐酸普马司他；盐酸普啉司他；普啉司他盐酸盐；(S)-2,2-二甲基-4-对(4-吡啶氧基)苯基)磺酰基)-3-硫代吗啉羰碳异羟肟酸盐酸盐；(S)-2,2-Dimethyl-4-((p-(4-pyridyloxy)phenyl)sulfonyl)-3-thiomorpholinecarbohydroxamic acid hydrochloride, AG3340 hydrochloride, AG-3340 hydrochloride, AG 3340 hydrochloride

Empirical Formula (Hill Notation): C18H21N3O5S2 · HCl CAS号: 192329-42-3 (free base) 分子量: 459.97 PubChem化学物质编号: 329823770 NACRES: NA.77
制造商品牌: 西格玛 Sigma-Aldrich
货号（SKU）: PZ0198
CAS号: 192329-42-3
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¥1,809.10

说明

一般描述

Prinomastat comprises hydroxamic acid group and chelates with zinc ion.[1]
 

应用

Prinomastat hydrochloride has been used as an antagonist for metalloproteinases (MMPs) in Crotalus atrox venom samples[2] and mouse embryo cultures.[3] It may be used as a MMP-2 inhibitor in HepG2 cells.[4]
 

生化/生理作用

Prinomastat is a matrix metalloprotease (MMP) inhibitor with selectivity for MMPs 2, 3, 9, 13, and 14. Inhibition of these MMPs has been postulated to block tumor invasion and metastasis. It is extremely potent at MMP-3 and MMP-2 with IC50s, 30 pM & 50 pM, respectively.
 

其他说明

This compound was developed by Pfizer for Cytoskeleton & Extracellular Matrix research. To learn more about Sigma′s partnership with Pfizer and view other authentic, high-quality Pfizer compounds, visit sigma.com/bsm-pfizer.
To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.
 

法律信息

Sold for research purposes under agreement from Pfizer Inc.
Pfizer is a registered trademark of Pfizer, Inc.
 
 

属性

质量水平

100

检测方案

≥95% (HPLC)

形式

powder

manufacturer/tradename

Pfizer®

颜色

white to beige

溶解性

H2O: 15 mg/mL (clear solution)

创始人

Pfizer

储存温度

room temp

SMILES string

Cl.CC1(C)SCCN([C@H]1C(=O)NO)S(=O)(=O)c2ccc(Oc3ccncc3)cc2

InChI

1S/C18H21N3O5S2.ClH/c1-18(2)16(17(22)20-23)21(11-12-27-18)28(24,25)15-5-3-13(4-6-15)26-14-7-9-19-10-8-14;/h3-10,16,23H,11-12H2,1-2H3,(H,20,22);1H/t16-;/m0./s1

InChI key

UQGWXXLNXBRNBU-NTISSMGPSA-N

 

安全信息

象形图

Health hazard
GHS08

警示用语：

Danger

危险声明

H360

危险分类

Repr. 1B

储存分类代码

6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

商品规格
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储存温度 Storage temp.常温阴凉避光
全球实时库存 Availability √美国St. Louis ≥ 20 | 欧洲Eur. ≥ 16 | 東京Tokyo ≥ 5 | 香港与北京 ≥ 20
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