尿酸，Uric acid；BioXtra, ≥99% (HPLC)

图片 尿酸，Uric acid；BioXtra, ≥99% (HPLC)
2,6,8-三羟基嘌呤；2,6,8-Trihydroxypurine；Empirical Formula (Hill Notation): C5H4N4O3 CAS号: 69-93-2 分子量: 168.11 Beilstein: 156158 EC 号: 200-720-7 MDL编号: MFCD00005712 PubChem化学物质编号: 24900620 NACRES: NA.55
制造商品牌: 西格玛 Sigma-Aldrich
货号（SKU）: U0881
CAS号: 69-93-2
MDL号: MFCD00005712
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¥681.45

说明

尿酸是人类嘌呤降解的终产物。它是由黄嘌呤氧化酶对黄嘌呤的作用形成的。尿酸水平升高在临床上可能表现为痛风。在人类以外的物种中，尿酸可以进一步代谢。在灵长类动物以外的哺乳动物中，尿酸转化为尿囊素。在硬骨鱼类中，尿囊素进一步转化为尿囊酸，尿囊酸被水解成尿素和乙醛酸。尿酸也可用于嘌呤的生物合成。它已被研究为过氧亚硝酸盐等生物自由基的清除剂。尿酸的高效液相色谱（HPLC）和气相色谱-质谱（GC-MS）方法已经发表。尿酸促进血管平滑肌细胞中单核细胞化学引诱蛋白-1（MCP-1）的表达。

一般描述

Uric acid is the terminal product of purine degradation in humans.[1] It is formed from the action of xanthine oxidase upon xanthine. Elevated levels of uric acid may clinically be manifested as gout. In species other than humans, uric acid can be further metabolized. In mammals other than primates, uric acid is converted to allantoin.[1] In teleost fish, allantoin is further converted to allantoate, which is hydrolyzed to urea and glyoxylate. Uric acid may also be used in the biosynthesis of purines. It has been studied as a scavenger of biological free radicals like peroxynitrite.[2][1] High-performance liquid chromatography (HPLC) and gas chromatography-mass spectrometry (GC-MS) methods for uric acid have been published. Uric acid promotes monocyte chemoattractant protein-1 (MCP-1) expression in vascular smooth muscle cells.[3]
 

应用

Uric acid has been used:
  • to prepare monosodium urate (MSU) crystals to study its effect on nuclear localization leucine-rich-repeat protein 1 (NLRP1) gene expression[2]
  • as a reductant to test its protective potential against met-myoglobin formation[4]
  • to prepare MSU to study its use as specific ligand of Clec12a[5].

 

属性

生物来源

animal (seabird feces (guano))

质量水平

200

产品线

BioXtra

测定

≥99% (HPLC)

形式

powder

杂质

≤0.005% Phosphorus (P)

灼烧残渣

≤0.1%

mp

>300 °C (lit.)

溶解性

1 M NaOH: soluble 50 mg/mL, clear, faintly yellow

痕量阳离子

Al: ≤0.005%
Ca: ≤0.01%
Cu: ≤0.0005%
Fe: ≤0.0005%
K: ≤0.05%
Mg: ≤0.001%
NH4+: ≤0.05%
Na: ≤0.1%
Pb: ≤0.001%
Zn: ≤0.0005%

SMILES string

O=C1NC(=O)C2=C(N1)NC(=O)N2

InChI

1S/C5H4N4O3/c10-3-1-2(7-4(11)6-1)8-5(12)9-3/h(H4,6,7,8,9,10,11,12)

InChI key

LEHOTFFKMJEONL-UHFFFAOYSA-N

 

安全信息

储存分类代码

13 - Non Combustible Solids

WGK

WGK 2

个人防护装备

Eyeshields, Gloves, type N95 (US)

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