奎宁；Quinine；suitable for fluorescence, anhydrous, ≥98.0% (dried material, NT)

图片 奎宁；Quinine；suitable for fluorescence, anhydrous, ≥98.0% (dried material, NT)
别名：6′-甲氧基辛可宁；6′-Methoxycinchonidine； Empirical Formula (Hill Notation): C20H24N2O2 CAS号: 130-95-0 分子量: 324.42 Beilstein/REAXYS Number: 91867 EC 号: 205-003-2 MDL编号: MFCD00198096 PubChem化学物质编号: 57647993 NACRES: NA.32
制造商品牌: 西格玛 Sigma-Aldrich
货号（SKU）: 22620
CAS号: 130-95-0
MDL号: MFCD00198096
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¥638.00

说明

一般描述

Quinine, also known as 6′-Methoxycinchonidine is a fluorescent reagent. The quantum yield of Quinine is 23% higher at 390 mµ excitation wavelength than at 313 mµ. The fluorescence polarization in the emission band of quinine in a rigid medium arises from two singlet states simultaneously. The emission spectra of quinine or 6-methoxyquinoline shifts towards the red zone when excited at 390 mµ.[1]
 

应用

Quinine was used in the following processes:
  • To study its in vitro antimalarial activity in combination with omeprazole.[2]
  • To analyze its effect on viscosity and friction of saliva.[3]
  • As a test agent to study its impact on the accumulation of the fluorescent P-glycoprotein (Pgp) substrates in P-glycoprotein overexpressing breast cancer cells.[4]
  • To study its influence on the pyramidal cell intrinsic properties, extracellular potassium transients, and epileptiform activity in vitro.[5]
  • As a reference compound to identify alkaloids by phytochemical screening of Deianira erubescens, Strychnos pseudoquina and Remijia ferruginea plants.[6]

生化/生理作用

钾通道阻断剂。
 
 

属性

质量水平

100

检测方案

≥98.0% (dried material, NT)

形式

powder

旋光性

[α]20/D −126±5°, c = 1% in chloroform

杂质

≤5% dihydroquinine (HPLC)

缺失

≤1% loss on drying, 110 °C

mp

173-175 °C (lit.)

溶解性

H2O: soluble

荧光

λex 347 nm; λem 448 nm in 0.5 M sulfuric acid

适用性

suitable for fluorescence

SMILES string

COc1ccc2nccc([C@@H](O)[C@@H]3C[C@@H]4CCN3C[C@@H]4C=C)c2c1

InChI

1S/C20H24N2O2/c1-3-13-12-22-9-7-14(13)10-19(22)20(23)16-6-8-21-18-5-4-15(24-2)11-17(16)18/h3-6,8,11,13-14,19-20,23H,1,7,9-10,12H2,2H3/t13-,14-,19-,20+/m0/s1

InChI key

LOUPRKONTZGTKE-WZBLMQSHSA-N

Gene Information

human ... ABCB1(5243) , CYP2C9(1559) , CYP2D6(1565)
rat ... Cyp2d1(266684) , Cyp2d2(25053) , Cyp2d3(24303) , Cyp2d4v1(171522)

 

安全信息

象形图

Exclamation mark
GHS07

警示用语：

Warning

危险声明

H302 - H317

危险分类

Acute Tox. 4 Oral - Skin Sens. 1

储存分类代码

11 - Combustible Solids

WGK

WGK 1

个人防护装备

dust mask type N95 (US), Eyeshields, Faceshields, Gloves

商品规格
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储存温度 Storage temp.常温阴凉避光
全球实时库存 Availability √美国St. Louis ≥ 20 | 欧洲Eur. ≥ 16 | 東京Tokyo ≥ 5 | 香港与北京 ≥ 20
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