多粘菌素B硫酸盐，Polymyxin B sulfate salt；powder, BioReagent, suitable for cell culture, ≥6,000 USP units per mg

图片 多粘菌素B硫酸盐，Polymyxin B sulfate salt；powder, BioReagent, suitable for cell culture, ≥6,000 USP units per mg
别名：硫酸多粘菌素B；多黏菌素B硫酸盐；嗜气芽孢菌素； 阿罗多粘多胜菌素乙；阿如多粘；多粘菌素乙；Aerosporin; Polimixina B; Polimixina B [INN-Spanish]; Polymixin B; Polymyxine B; Polymyxine B [INN-French]; Polymyxinum B; Polymyxinum B [INN-Latin]; UNII-J2VZ07J96K

Empirical Formula (Hill Notation): C55H96N16O13 · 2H2SO4 CAS号: 1405-20-5 分子量: 1385.61 EC 号: 215-774-7 MDL编号: MFCD00131991 NACRES: NA.76
制造商品牌: 西格玛 Sigma-Aldrich
货号（SKU）: P4932
CAS号: 1405-20-5
MDL号: MFCD00131991
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¥1,690.00

说明

多粘菌素B是多粘菌蛋白类抗生素中的一种，从多粘菌芽孢杆菌和相关物种的不同菌株中获得。它含有一个环状七肽单元和一个三肽侧链，由脂肪酰基残基N-酰化。多粘菌素B硫酸盐通常用于治疗革兰氏阴性细菌感染。
化学结构：肽

一般描述

Polymyxin B is a member of the polymyxin group of antibiotics, obtained from different strains of Bacillus polymyxa and related species. It contains a cyclic heptapeptide unit and a tripeptide side chain, which is N-acylated by a fatty acyl residue. Polymyxin B sulfate salt is generally used for the treatment of Gram-negative bacterial infections.
Chemical structure: peptide
 

应用

Polymyxin B sulfate salt has been used:
  • for the treatment of BAC-1.2F5 murine macrophages as an LPS (lipopolysaccharide) inhibitor
  • as positive and negative control during microbicidal concentration (MCC) assay

生化/生理作用

Polymyxin B sulfate has been used clinically to treat infections of the urinary tract, meninges and blood stream caused by susceptible strains of Pseudomonas aeruginosa. It also has been used in studying multidrug-resistant pathogens, as an immobilized agent for removal of endotoxins, and to induce pore formation in the membranes of cortex cells from excised sorghum roots.
作用方式：多粘菌素B硫酸盐结合到细菌脂多糖的脂质部分†上，通过诱导足够大的孔来破坏细胞质膜，使核苷酸泄漏到细菌的细胞壁中。 这可破环细胞质膜的半透性。

抗菌谱：对大多数革兰氏阴性杆菌，包括 大肠杆菌 ，真菌和革兰氏阳性菌都有杀菌作用。
 

注意

As supplied, the product should be stored at 2-8°C in the dark. No change was observed in retained samples after three years′ of storage in these conditions. Stock solutions should be sterile filtered and stored at 2-8°C. They are stable at 37°C for 5 days.
 

制备说明

Polymyxin B sulfate is soluble in water at 50 mg/mL, producing a very slightly hazy, colorless to yellow solution. It has only minimal solubility in any organic solvent. For example, it has a solubility of 0.115 mg/mL in ethanol.
 

其他说明

1mu,5mu
Keep container tightly closed in a dry and well-ventilated place.Keep in a dry place.
 
 

属性

产品线

BioReagent

质量水平

200

形式

powder

效能

≥6,000 USP units per mg

technique(s)

cell culture | mammalian: suitable

溶解性

H2O: 50 mg/mL

抗生素抗菌谱

Gram-negative bacteria

作用机制

cell membrane | interferes

储存温度

2-8°C

InChI

1S/C48H82N16O13.H2O4S/c1-27(2)24-37-47(76)59-32(11-19-52)41(70)56-31(10-18-51)43(72)61-35(14-22-65)39(68)54-21-13-34(45(74)57-33(12-20-53)44(73)64-38(48(77)63-37)25-28-6-4-3-5-7-28)60-42(71)30(9-17-50)58-46(75)36(15-23-66)62-40(69)29(8-16-49)55-26-67;1-5(2,3)4/h3-7,26-27,29-38,65-66H,8-25,49-53H2,1-2H3,(H,54,68)(H,55,67)(H,56,70)(H,57,74)(H,58,75)(H,59,76)(H,60,71)(H,61,72)(H,62,69)(H,63,77)(H,64,73);(H2,1,2,3,4)

InChI key

HNDFYNOVSOOGDU-UHFFFAOYSA-N

 

安全信息

象形图

Exclamation mark
GHS07

警示用语：

Warning

危险声明

H302

危险分类

Acute Tox. 4 Oral

储存分类代码

11 - Combustible Solids

WGK

WGK 3

个人防护装备

dust mask type N95 (US), Eyeshields, Gloves

商品规格
属性名称属性值
储存温度 Storage temp.2-8°C冷藏
全球实时库存 Availability √美国St. Louis ≥ 50 | 欧洲Eur. ≥ 12 | 東京Tokyo ≥ 20 | 香港与北京 ≥ 50
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