卡普瑞林酒石酸盐，Capromorelin tartrate；≥98% (HPLC)

图片 卡普瑞林酒石酸盐，Capromorelin tartrate；≥98% (HPLC)
别名：酒石酸卡普瑞林；CP 424391-18；CP-424391 tartrate；2-Amino-N-(1R)-2-(3aR)-2,3,3a,4,6,7-hexahydro-2-methyl-3-oxo-3a-(phenylmethyl)-5H-pyrazolo4,3-cpyridin-5-yl-2-oxo-1-propanamide (2R,3R)-2,3-dihydroxybutanedioate

Empirical Formula (Hill Notation): C28H35N5O4 · C4H6O6 CAS号: 193273-69-7 分子量: 655.70 MDL编号: MFCD25977748 PubChem化学物质编号: 329823835
制造商品牌: 西格玛 Sigma-Aldrich
货号（SKU）: PZ0317
CAS号: 193273-69-7
MDL号: MFCD25977748
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¥1,091.58

说明

一般描述

Capromorelin tartrate has been used in human clinical trials as a treatment for frailty in elderly adults.[1]
Capromorelin tartrate is an agonist of GHSR1a (ghrelin) receptors. It possesses structural homology with pyrazolinone-piperidine dipeptides.[2]
 

生化/生理作用

Capromorelin tartrate is a potent ghrelin receptor agonist/growth hormone secretagogue (Ki = 7 nM). In rat pituitary cells, Capromorlelin incudes growth hormone (GH) secretion with an EC50 of 3 nM. Capromorelin also increases gastric motility and has been studied recently in patients with spinal cord injuries.
 

其他说明

This compound was developed by Pfizer for Cytokines & Growth Factors research. To learn more about Sigma′s partnership with Pfizer and view other authentic, high-quality Pfizer compounds, visit sigma.com/bsm-pfizer.
 

法律信息

Sold for research purposes under agreement from Pfizer Inc.
Pfizer is a registered trademark of Pfizer, Inc.
 
 

属性

质量水平

100

测定

≥98% (HPLC)

形式

powder

mfr. no.

Pfizer®

颜色

white to beige

溶解性

H2O: 20 mg/mL, clear

创始人

Pfizer

储存温度

room temp

SMILES string

O=C1N(C)N=C2CCN(C(C@H(NC(C(C)(C)N)=O)COCC3=CC=CC=C3)=O)CC@21CC4=CC=CC=C4.OC(C@H(O)C@@H(O)C(O)=O)=O

InChI

1S/C28H35N5O4.C4H6O6/c1-27(2,29)25(35)30-22(18-37-17-21-12-8-5-9-13-21)24(34)33-15-14-23-28(19-33,26(36)32(3)31-23)16-20-10-6-4-7-11-20;5-1(3(7)8)2(6)4(9)10/h4-13,22H,14-19,29H2,1-3H3,(H,30,35);1-2,5-6H,(H,7,8)(H,9,10)/t22-,28-;1-,2-/m11/s1

InChI key

MJGRJCMGMFLOET-MYPSAZMDSA-N

 

安全信息

象形图

Exclamation mark
GHS07

警示用语：

Warning

危险声明

H315 - H319 - H335

危险分类

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

靶器官

Respiratory system

储存分类代码

11 - Combustible Solids

WGK

WGK 3

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