他克莫司，Tacrolimus；FK-506, Streptomyces sp.

图片 他克莫司，Tacrolimus；FK-506, Streptomyces sp.
别名：FK-506, Streptomyces sp., Tacrolimus； Empirical Formula (Hill Notation): C44H69NO12 CAS号: 104987-11-3 分子量: 804.02 MDL编号: MFCD00869853
制造商品牌: 默克 Merck , 西格玛 Sigma-Aldrich
货号（SKU）: 342500
CAS号: 104987-11-3
MDL号: MFCD00869853
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¥976.00

说明

一般描述

Immunosuppressant that blocks T cell proliferation in vitro by inhibiting the generation of several lymphokines, especially IL-2. Shown to inhibit the activity of FK-506 binding protein, thereby reversing its effects on sarcoplasmic reticulum Ca2+ release. Inhibits the Ca2+-dependent phosphatase, Protein Phosphatase 2B (Calcineurin; Cat. No. 539568), as well as Na+,K+-ATPase in nephron segments. Also shown to inhibit aldosterone-induced synthesis of Giα-3 protein.
Immunosuppressant that blocks T-cell proliferation in vitro by inhibiting the generation of several lymphokines, especially IL-2. Shown to inhibit the activity of FK-506 Binding Protein, thereby reversing its effects on sarcoplamic reticulum Ca2+ release. Shown to inhibit the Ca2+-dependent phosphatase, Calcineurin (Cat. No. 539565), as well as Na+-K+-ATPase in nephron segments. Also shown to inhibit aldosterone-induced synthesis of Giα-3 protein.
 

生化/生理作用

Cell permeable: no
Primary Target
Immunosuppressant that blocks T cell proliferation
Product does not compete with ATP.
Reversible: no
 

警告

Toxicity: Toxic (F)
 

重悬

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
 

其他说明

Asano, K., et al. 1996. In Vivo 10, 537.
McCall, E., et al. 1996. Circ. Res. 79, 1110.
Raufman, J.P., et al. 1996. J. Biol. Chem. 271, 19877.
Rokaw, M.D., et al. 1996. Am. J. Physiol. 271, C194.
Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
 

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
 
 

属性

质量水平

100

测定

≥98% (TLC)

形式

solid

manufacturer/tradename

Calbiochem®

储存条件

OK to freeze
desiccated

颜色

off-white

溶解性

DMSO: 10 mg/mL
methanol: 5 mg/mL

运输

ambient

储存温度

2-8°C

InChI

1S/C44H69NO12.H2O/c1-10-13-31-19-25(2)18-26(3)20-37(54-8)40-38(55-9)22-28(5)44(52,57-40)41(49)42(50)45-17-12-11-14-32(45)43(51)56-39(29(6)34(47)24-35(31)48)27(4)21-30-15-16-33(46)36(23-30)53-7;/h10,19,21,26,28-34,36-40,46-47,52H,1,11-18,20,22-24H2,2-9H3;1H2/b25-19+,27-21+;/t26-,28+,29+,30?,31+,32-,33+,34-,36+,37-,38-,39+,40+,44+;/m0./s1

InChI key

NWJQLQGQZSIBAF-HZXKVGIDSA-N

 

安全信息

象形图

Skull and crossbonesHealth hazard
GHS06,GHS08

警示用语：

Danger

危险分类

Acute Tox. 3 Oral - Repr. 2 - STOT RE 2

储存分类代码

6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

商品规格
属性名称属性值
储存温度 Storage temp.2-8°C冷藏
全球实时库存 Availability √美国St. Louis ≥ 50 | 欧洲Eur. ≥ 12 | 東京Tokyo ≥ 20 | 香港与北京 ≥ 50
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