丙硫异烟胺，Prothionamide；≥99% (HPLC)

别名：2-丙基异烟基硫代酰胺；2-丙基硫代异烟酰胺；2-丙基异烟基硫代酰胺；2-丙基-4-吡啶硫代碳酰胺；2-丙基-4-吡啶硫代硫代酰胺；丙硫磺酰胺；2-propylisonicotinylthioamide；2-propylthioisonicotinamide；2-Propylisonicotinylthioamide；2-Propyl-4-pyridinecarbothioamide；2-propyl-4-pyridinecarbothioamide；Prothionamide

Empirical Formula (Hill Notation): C9H12N2S CAS号: 14222-60-7 分子量: 180.27 MDL编号: MFCD00464119 PubChem化学物质编号: 329824982 NACRES: NA.85

制造商品牌: 西格玛 Sigma-Aldrich

货号（SKU）: SMB00387

CAS号: 14222-60-7

MDL号: MFCD00464119

签订合同 √ 正规发票 √ 技术支持 √ 质量保障 √ 全程可追溯 √

目录价.SKU-Variant

1g
10g [+¥3,432.50]
25g [+¥5,573.21]
100g [+¥11,745.38]

¥757.90

数量:

说明

丙硫异烟胺是乙硫异烟胺的类似物，比乙硫异烟胺耐受性更好，毒性更小。它在 α 位含有一个丙基而不是一个乙基。
化学结构：吡啶

Prothionamide 是用于麻风病和结核病的二线药物。它对结核分枝杆菌非常有效。在耐多药结核病 (MDR-TB) 患者中，丙硫异烟胺会导致肝炎的发展。在极少数情况下，它会导致耐多药结核病患者出现嗜酸性粒细胞增多和全身症状 (DRESS) 的药物反应。 DRESS 的特点是发热、血液学异常、皮疹和内脏器官破坏。

一般描述

Prothionamide is an analogue of ethionamide, and is better tolerated and less toxic than ethionamide. It contains a propyl group instead of an ethyl group at the α position.

Chemical structure: pyridine

生化/生理作用

Prothionamide is the second line of drug used in leprosy and in tuberculosis. It is highly effective against Mycobacterium tuberculosis. In patients with multidrug-resistant tuberculosis (MDR-TB), prothionamide causes the development of hepatitis. In rare cases, it causes drug reaction with eosinophilia and systemic symptoms (DRESS) in patients with MDR-TB. DRESS is characterized by fever, hematologic abnormalities, skin eruption, and internal organ disruption.

其他说明

Keep container tightly closed in a dry and well-ventilated place. Storage class (TRGS 510): Non Combustible Solids

属性

质量水平

200

测定

≥99% (HPLC)

形式

powder

储存条件

(Keep container tightly closed in a dry and well-ventilated place. Storage class (TRGS 510) Non Combustible liquids.)

颜色

yellow

抗生素抗菌谱

mycobacteria

作用机制

enzyme | interferes

储存温度

−20°C

SMILES string

NC(C1=CC(CCC)=NC=C1)=S

InChI

1S/C9H12N2S/c1-2-3-8-6-7(9(10)12)4-5-11-8/h4-6H,2-3H2,1H3,(H2,10,12)

InChI key

VRDIULHPQTYCLN-UHFFFAOYSA-N

安全信息

象形图

GHS07

警示用语：

Warning

危险声明

H302

危险分类

Acute Tox. 4 Oral

储存分类代码

11 - Combustible Solids

WGK

WGK 3

商品规格

属性名称	属性值
储存温度 Storage temp.	-20°C低温冷冻
全球实时库存 Availability √	美国St. Louis ≥ 30 \| 欧洲Eur. ≥ 10 \| 東京Tokyo ≥ 9 \| 香港与北京 ≥ 30

商品标签 [tags]

丙硫异烟胺 (1)

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