马血红蛋白，Hemoglobin equine [Hb]；lyophilized powder

图片 马血红蛋白，Hemoglobin equine [Hb]；lyophilized powder
别名：血红蛋白来源于马，高铁血红蛋白， equine hemoglobin，Methemoglobin

CAS号 9047-09-0 MDL number MFCD00131282 NACRES NA.61
制造商品牌: 西格玛 Sigma-Aldrich
货号（SKU）: H4632
CAS号: 9047-09-0
MDL号: MFCD00131282
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¥1,576.00

说明

血红蛋白是红血球的主要成分，并负责其红色。其在红细胞中的正常浓度为34%。首先阐明了马血红蛋白的结构。它由血红素（铁原卟啉IX族）和四条多肽链组成。马的胎儿血红蛋白和成人血红蛋白在结构上是相同的。
马血红蛋白可被用作标准蛋白质：
测试傅里叶变换红外光谱（FT-IR）中用于蛋白质二级结构测定的固体薄膜取样方法
酶消化后毛细管反相液相色谱-串联质谱（LC/MS/MS）
用于定量浮游甲壳动物大型蚤的血红蛋白含量
血红蛋白是脊椎动物最重要的呼吸蛋白质，因为它能够将氧气从肺部输送到身体组织，并促进二氧化碳的返回运输。亚铁（Fe2+/Fe3+）平衡是血液氧合的生理指标。脱氧血红蛋白通过将亚硝酸盐还原为一氧化氮（NO）来辅助反馈回路，一氧化氮是一种血管扩张剂，可以增强血液流向缺氧组织。马的胎儿和成人血红蛋白对2,3-二磷酸甘油酸（2,3-DPG）的亲和力存在差异。镰状细胞贫血与珠蛋白基因突变有关。
用作氧气转运体，NO清除

一般描述

Hemoglobin is the major component of red blood cells and is responsible for their red color. Its normal concentration in erythrocytes is 34%. The structure of horse hemoglobin was elucidated first. It comprises heme (iron protoporphyrin IX group) and four polypeptide chains. The fetal and adult hemoglobin of horse are structurally identical.
 

应用

Hemoglobin equine has been used as a standard protein:
  • to test solid-film sampling methodology in Fourier transform infrared spectroscopy (FT-IR) for protein secondary structure determination
  • in capillary reversed-phase liquid chromatography-tandem mass spectrometry (LC/MS/MS) post enzymatic digestion
  • for quantification of hemoglobin content from the planktonic crustacean, Daphnia magna

生化/生理作用

Hemoglobin is the most important respiratory protein of vertebrates by its ability to transport oxygen from the lungs to body tissues and to facilitate the return transport of carbon dioxide. The ferrous-ferric (Fe2+/Fe3+) balance is a physiological indicator of blood oxygenation. Deoxygenated hemoglobin accessorizes a feedback loop by reducing nitrite to nitric oxide (NO), a vasodilator which enhances blood flow to oxygen-deprived tissues. The fetal and adult hemoglobin from horse display differences in their affinity towards 2,3-diphosphoglycerate (2,3-DPG). Mutation in the globin gene is implicated in sickle cell anemia.
Oxygen transporter, NO scavenger
 

注意

Since native hemoglobin is readily oxidized in air, these preparations may be predominantly methemoglobin.
 
 

属性

生物来源

horse

质量水平

200

形式

lyophilized powder

technique(s)

protein quantification: suitable

溶解性

H2O: soluble 10 mg/mL

UniProt登记号

P01958
P02062

储存温度

2-8°C

Gene Information

horse ... HBA(100036557) , HBB(100054109)

 

安全信息

储存分类代码

13 - Non Combustible Solids

WGK

WGK 3

个人防护装备

Eyeshields, Gloves, type N95 (US)

商品规格
属性名称属性值
储存温度 Storage temp.2-8°C冷藏
全球实时库存 Availability √美国St. Louis ≥ 50 | 欧洲Eur. ≥ 12 | 東京Tokyo ≥ 20 | 香港与北京 ≥ 50
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