一种被认为是光周期哺乳动物中光诱导抗性腺激素活性的调节剂的激素。对抗足叶乙甙对骨髓细胞的凋亡作用。褪黑素受体与G蛋白系统偶联。抑制大鼠小脑一氧化氮合酶（NOS）。
一种被认为是光周期哺乳动物中光诱导抗性腺激素活性介体的激素。对抗足叶乙甙对骨髓细胞的凋亡作用。褪黑素受体与G蛋白系统偶联。具有抗氧化性能。对Aβ肽具有神经保护作用。抑制大鼠小脑一氧化氮合酶（NOS）。也可作为过氧亚硝酸盐清除剂。
General description
A hormone that has been postulated as being a mediator of photic-induced anti-gonadotropic activity in photoperiodic mammals. Counteracts the apoptotic effects of etoposide in bone marrow cells. Melatonin receptors are coupled to a G-protein system. Inhibits rat cerebellar nitric oxide synthase (NOS).
A hormone that has been postulated as the mediator of photo-induced anti-gonadotropic activity in photoperiodic mammals. Counteracts the apoptotic effects of etoposide in bone marrow cells. Melatonin receptors are coupled to a G-protein system. Exhibits antioxidant properties. Has neuroprotective effects against Aβ peptides. Inhibits rat cerebellar nitric oxide synthase (NOS). Also acts as a peroxynitrite scavenger.
Biochem/physiol Actions
Cell permeable: no
Primary Target
rat NOS
Product does not compete with ATP.
Reversible: no
Warning
Toxicity: Standard Handling (A)
Reconstitution
Following reconstiution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Other Notes
Pappolla, M.A., et al. 2002. J. Pineal Res.32, 135.
Reiter, R.J., and Tan, D.X. 2002. Ann. N.Y. Acad. Sci.957, 341.
Cuzzocrea, S., et al. 1998. J. Pineal Res. 25, 24.
Maestroni, G.J., et al. 1994. Cancer Res. 54, 2429.
Pozo, D., et al. 1994. Life Sciences55, PL455.
性质
| Quality Level | 100 |
| assay | ≥98% (HPLC) |
| form | powder |
| storage condition | OK to freeze |
| | protect from light |
| storage conditions： | +2C to +8C |
| color | white to slightly yellow |
| solubility | methanol: 50 mg/mL |
| shipped in | ambient |
| InChI | 1S/C13H16N2O2/c1-9(16)14-6-5-10-8-15-13-4-3-11(17-2)7-12(10)13/h3-4,7-8,15H,5-6H2,1-2H3,(H,14,16)| InChI key | DRLFMBDRBRZALE-UHFFFAOYSA-N | |
安全信息
个人防护装备 Eyeshields, Gloves, type N95 (US)
RIDADR NONH for all modes of transport
